{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:07:16Z","timestamp":1784012836122,"version":"3.55.0"},"reference-count":67,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302490"],"award-info":[{"award-number":["82302490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) employs sophisticated strategies to subvert host innate immunity, a critical determinant of viral establishment and dissemination. Nevertheless, the immunomodulatory functions of coronavirus structural proteins remain incompletely understood. Here, we identify the evolutionarily conserved membrane (M) protein of SARS\u2010CoV\u20102 as an innate immune antagonist that suppresses nuclear factor kappa\u2010B (NF\u2010\u03baB) activation. Functional assays revealed that the M protein markedly inhibited NF\u2010\u03baB activation and reduced proinflammatory cytokine production in vitro. In lung epithelial M\u2010expressing mouse, M significantly attenuated LPS\u2010induced inflammation. Mechanistically, M protein from diverse coronaviruses directly interacts with host Toll\u2010interacting protein (TOLLIP), stabilizing TOLLIP\u2012IRAK1 complex, preventing IRAK1 activation, thereby suppressing downstream NF\u2010\u03baB signaling and creating a permissive cellular microenvironment for viral replication. We mapped a conserved linker region within the M protein as the core motif mediating this interaction. This binding is highly conserved across coronaviruses, highlighting the fundamental role of the M\u2013TOLLIP axis in viral immune evasion. Our findings reveal a conserved pan\u2010coronavirus immune evasion strategy by which coronaviruses target TOLLIP to subvert Toll\u2010like receptor (TLR)\u2013NF\u2010\u03baB signaling. The conserved M\u2010linker region thus represents a potential broad\u2010spectrum antiviral target, providing a structural framework for developing next\u2010generation antivirals against current and emerging coronavirus threats.<\/jats:p>","DOI":"10.1002\/mco2.70821","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:00:32Z","timestamp":1781697632000},"source":"Crossref","is-referenced-by-count":0,"title":["Coronavirus M Protein Hijacks Toll\u2010Interacting Protein (TOLLIP) to Suppress NF\u2010\u03baB Signaling and Promote Immune Evasion"],"prefix":"10.1002","volume":"7","author":[{"given":"Yabin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital Sichuan University  Chengdu China"},{"name":"Biosafety Laboratory International Center for Biological and Translational Research West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Kang","sequence":"additional","affiliation":[{"name":"Institute of Rare Diseases Frontiers Science Center for Disease\u2010Related Molecular Networks West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Biosafety Laboratory International Center for Biological and Translational Research West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songjun","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senren","family":"Xue","sequence":"additional","affiliation":[{"name":"Biosafety Laboratory International Center for Biological and Translational Research West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of High Altitude Medicine and Center for High Altitude Medicine West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Biosafety Laboratory International Center for Biological and Translational Research West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Biosafety Laboratory International Center for Biological and Translational Research West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5008-0339","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Biosafety Laboratory International Center for Biological and Translational Research West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital Sichuan University  Chengdu China"},{"name":"Department of High Altitude Medicine and Center for High Altitude Medicine West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01136-X"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00662-x"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"162","article-title":"SARS\u2010CoV\u20102 Variant Biology: Immune Escape, Transmission and Fitness","volume":"21","author":"Carabelli A. 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