{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:07:10Z","timestamp":1784012830740,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82061148016"],"award-info":[{"award-number":["82061148016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230057"],"award-info":[{"award-number":["82230057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272859"],"award-info":[{"award-number":["82272859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203087"],"award-info":[{"award-number":["82203087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2505101"],"award-info":[{"award-number":["2022YFC2505101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0552502"],"award-info":[{"award-number":["2025ZD0552502"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Triple\u2010negative breast cancer (TNBC) has a poor prognosis and limited treatment options. Although programmed death protein 1 (PD\u20101) inhibitor\u2010based chemotherapy and its combination with antiangiogenic agents are increasingly used clinically, comparative effectiveness data are lacking. This real\u2010world study compared chemoimmunotherapy (IC) versus chemoimmunotherapy plus antiangiogenic therapy (ICA) in advanced TNBC. Among 218 eligible patients, the ICA group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0119) showed a significantly higher disease control rate (DCR) than the IC group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a099) (85.7\u00a0vs. 73.7%,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.009). Notable numerical improvements were observed in high\u2010risk subgroups: in patients with \u22653 prior lines (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a056), ICA improved DCR by 26.0% (81.6\u00a0vs. 55.6%,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.039) and prolonged PFS by 2.9 months (5.3\u00a0vs. 2.4 months,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.031). In those with brain metastases (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a024), ICA increased DCR by 50.0% (83.3\u00a0vs. 33.3%,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.017, posthoc power\u00a0=\u00a055.4%), with extended progression\u2010free survival (PFS) (+4.0 months) and overall survival (OS) (+12.6 months). Early recurrence patients (disease\u2010free interval (DFI)\u00a0&lt;\u00a012 months,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a054) showed a 28.6% higher DCR with ICA (78.6\u00a0vs. 50.0%,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.024). This study highlights the potential of adding antiangiogenic therapy to chemoimmunotherapy, particularly for high\u2010risk or refractory advanced TNBC patients, suggesting a strategy that may overcome programmed death ligand 1 (PD\u2010L1)\u2010related resistance and warrants prospective validation.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70839","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:45:42Z","timestamp":1783320342000},"source":"Crossref","is-referenced-by-count":0,"title":["Chemoimmunotherapy Combined With Antiangiogenic Therapy in Advanced Triple\u2010Negative Breast Cancer: Real\u2010World Outcomes From a Retrospective Cohort Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Yudong","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0817-5238","authenticated-orcid":false,"given":"Jinna","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Jin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunying","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianfeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongna","family":"Lai","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Gong","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Breast Tumor Center, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19323"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1177"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.7554"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4971"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.154"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30904-X"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.07.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0131-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33378"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy517"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy518"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4537-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4224"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809615"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910549"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.05.801"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.04.001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102855"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00496-y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113516"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2179"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000696"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03734-3"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30569-0"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02677-x"},{"key":"e_1_2_11_28_1","unstructured":"National Comprehensive Cancer Network.NCCN Guidelines: breast cancer version 2.2024."},{"issue":"11","key":"e_1_2_11_29_1","first-page":"1414","article-title":"ESMO triple\u2010negative breast cancer living guidelines","volume":"36","author":"Curigliano G.","year":"2025","journal-title":"Ann Oncol"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp-2022-208637"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz394.009"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000001062"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-023-01724-2"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.20.00412"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2018.29"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12624"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-4313"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14040965"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2009.07.002"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14061160"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5021"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2023.07.008"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","unstructured":"A Phase II Clinical Study of Adebrelimab and bevacizumab Combined With Cisplatin\/Carboplatin in Triple\u2010negative Breast Cancer Patients With Brain Metastases In:ASCO 2025:Rapid Oral Abstract 1018.","DOI":"10.1200\/JCO.2025.43.16_suppl.1018"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.05.023"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225835"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08320-7"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1119611"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70839","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:40:00Z","timestamp":1784011200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/mco2.70839"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70839","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"e70839"}}