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The limitations of current therapeutic modalities highlight the pressing need for continued innovation in therapeutic interventions. This review comprehensively delineated the knowledge architecture, research focal points, and emerging directions in DR therapeutics. Targeted biological agents have recently emerged as principal research directions in DR therapy and hold substantial promise. They are expected to achieve the goals of blocking disease progression more persistently, effectively, and less invasively than nonbiological therapeutics through multitarget synergy and long\u2010acting sustained\u2010release formulations. In clinical practice, the paradigm of DR therapy has shifted toward personalized and precision medicine, with optimized subthreshold micropulse laser as a promising adjunctive therapy for enhancing long\u2010term treatment outcomes. Looking ahead, therapeutic monitoring in DR may evolve beyond conventional morphological grading to incorporate multimodal precision diagnostics, artificial intelligence\u2010driven broad\u2010spectrum screening, and biomarker\u2010based early warning systems. This review concludes with a discussion on prospects and challenges in DR therapeutics, with special emphasis on emerging drug candidates, recent clinical trial findings, and novel insights that may inform the next generation of therapeutic interventions for DR.<\/jats:p>","DOI":"10.1002\/mco2.70849","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:02:51Z","timestamp":1783407771000},"source":"Crossref","is-referenced-by-count":0,"title":["Current Landscape and Future Perspectives of Diabetic Retinopathy Therapy: Pharmacological Targets, Precision Laser Technology, and Clinical Evidence"],"prefix":"10.1002","volume":"7","author":[{"given":"Xinying","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Affiliated Jiangyin Hospital of Nantong University (Jiangyin People's Hospital)  Jiangyin Jiangsu PR China"},{"name":"Department of Ophthalmology, Southwest Hospital\/Southwest Eye Hospital Third Military Medical 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