{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:07:04Z","timestamp":1784012824382,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372954"],"award-info":[{"award-number":["82372954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intracranial efficacy of crizotinib and optimal postprogression therapies in c\u2010ros oncogene 1 (ROS1)\u2010positive non\u2013small cell lung cancer(NSCLC) remain under\u2010explored. We performed a multicenter real\u2010world study across 17 Chinese hospitals (2015\u20132024) in 325 ROS1\u2010positive NSCLC patients to evaluate the intracranial efficacy of crizotinib and postprogression treatment strategies. Crizotinib achieved an overall response rate(ORR) of 78.5% and a median progression\u2010free survival (PFS) of 22.4 months. Patients with baseline brain metastases had a 66.7% intracranial response rate and a median central nervous system (CNS)\u2010PFS of 22.2 months, demonstrating intracranial benefit. After progression, next\u2010generation ROS1 inhibitors (active against the G2032R resistance mutation, for example, taletrectinib and repotrectinib) significantly prolonged PFS compared to older\u2010generation targeted agents (median 13.9\u00a0vs. 4.4 months), especially among patients with secondary ROS1 resistance mutations (ORR 66.7% vs. 14.3%). However, due to greater availability in China, earlier agents like lorlatinib and entrectinib were commonly used after crizotinib failure. In our cohort, lorlatinib demonstrated superior efficacy to entrectinib, with a trend toward longer PFS and higher overall (34%\u00a0vs. 7%) and intracranial (50%\u00a0vs. 0%) response rates. This large real\u2010world study confirms crizotinib's intracranial benefit and underscores the importance of next\u2010generation ROS1 inhibitors and older\u2010generation agents like lorlatinib\u2014for improved patient outcomes after crizotinib resistance.<\/jats:p>","DOI":"10.1002\/mco2.70854","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:36:24Z","timestamp":1783928184000},"source":"Crossref","is-referenced-by-count":0,"title":["Intracranial Efficacy of Crizotinib and Postprogression Therapeutic Strategies in Advanced c\u2010ros Oncogene 1 (ROS1)\u2010Positive Non\u2013Small Cell Lung Cancer (NSCLC), a Multicenter Real\u2010World Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Zihua","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital  Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-3228","authenticated-orcid":false,"given":"Panwen","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Lung Cancer Center Precision Medicine Key Laboratory of Sichuan Province West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Geriatric Center Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sir Run Run Shaw Hospital Zhenjiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-2244","authenticated-orcid":false,"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Xiamen Key Laboratory of Antitumor Drug Transformation Research School of Medicine the First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangfeng","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Affiliated Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diansheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sichuan Clinical Research Center for Cancer Sichuan Cancer Center Sichuan Cancer Hospital &amp; Institute Affiliated Cancer Hospital of University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oncology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshan","family":"Cao","sequence":"additional","affiliation":[{"name":"Cancer Center Department of Medical Oncology and Radiation Sickness Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingzhi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology the Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0408-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.05.026"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406766"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz131"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2022.100406"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3302"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.03.020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.5587"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30690-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03025"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2022.100332"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30655-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2024.09.133"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.8519"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0484"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302299"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00731"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2972"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.07.44"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2984"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-019-00636-6"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107816"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107892"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504019X15509372008132"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.016"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02082-6"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107827"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.17.00063"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2452"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0917"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.1313"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.0539"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000468"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.5888"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz167"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.12.129"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00382-5"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.10613"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1385"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:40:03Z","timestamp":1784011203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/mco2.70854"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70854","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"e70854"}}