{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:39:51Z","timestamp":1792708791590,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102843"],"award-info":[{"award-number":["82102843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473258"],"award-info":[{"award-number":["82473258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFB1074"],"award-info":[{"award-number":["2023AFB1074"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Concurrent chemoradiotherapy (CCRT) followed by intrauterine brachytherapy is the standard treatment for locally advanced cervical cancer (LACC), yet its efficacy is frequently constrained by an immunosuppressive tumor microenvironment (TME). This randomized, single\u2010center, Phase II trial (\n                    <jats:italic>n<\/jats:italic>\n                    = 18; 2:1 allocation; high\u2010risk Stages III\u2013IVA LACC) investigated whether adding immunotherapy to CCRT (CICRT) could enhance early tumor regression and overcome immune suppression. In this exploratory analysis, CICRT demonstrated a numerical advantage in tumor reduction over CCRT alone, although the difference did not reach conventional statistical significance (mean residual tumor volume: 3.0% vs. 7.4%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.080, 95% CI: \u22129.3%\u20130.6%,\n                    <jats:italic>\u03b7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.180). Single\u2010cell RNA sequencing of paired biopsies (\n                    <jats:italic>n<\/jats:italic>\n                    = 12) revealed that CICRT was associated with pro\u2010inflammatory remodeling, characterized by the upregulation of MHC\u2010II and chemotaxis\u2010related genes in malignant cells and cancer\u2010associated fibroblasts. Notably, CICRT reduced regulatory T cell niches and exhausted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, alongside a phenotypic shift in tumor\u2010associated macrophages toward an inflammatory state. These findings demonstrate the potential of CICRT to enhance early tumor regression and mitigate TME suppression, providing an exploratory biological rationale for its therapeutic activity in LACC.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70856","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:57:06Z","timestamp":1783580226000},"source":"Crossref","is-referenced-by-count":1,"title":["Concurrent Chemoradiotherapy Plus Immunotherapy Versus Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer: A Randomized, Single\u2010Center, Phase II Trial of Early Tumor Regression and Pro\u2010Inflammatory Tumor Microenvironment Remodeling"],"prefix":"10.1002","volume":"7","author":[{"given":"Yuhan","family":"Sheng","sequence":"first","affiliation":[{"name":"Cancer Center Hubei Key Laboratory of Precision Radiation Oncology Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory of Biological Targeted Therapy Huazhong University of Science and Technology Ministry of Education  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Cancer Center Hubei Key Laboratory of Precision Radiation Oncology Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory of Biological Targeted Therapy Huazhong University of Science and Technology Ministry of Education  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Cancer Center Hubei Key Laboratory of Precision Radiation Oncology Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory of Biological Targeted Therapy Huazhong University of Science and Technology Ministry of Education  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Center Hubei Key Laboratory of Precision Radiation Oncology Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory of Biological Targeted Therapy Huazhong University of Science and Technology Ministry of Education  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cancer Center Hubei Key Laboratory of Precision Radiation Oncology Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory of Biological Targeted Therapy Huazhong University of Science and Technology Ministry of Education  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minggang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cancer Center Hubei Key Laboratory of Precision Radiation Oncology Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory of Biological Targeted Therapy Huazhong University of Science and Technology Ministry of Education  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00501-0"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2022-003801"},{"key":"e_1_2_13_5_1","unstructured":"\u201cCervical Cancer Survival Rates | Cancer 5\u2010Year Survival Rates \u201dAmerican Cancer Society accessed April 22 2025 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