{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:58Z","timestamp":1792043158286,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The optimal perioperative regimen for resectable hepatocellular carcinoma (HCC) remains undefined. This study evaluated the efficacy and safety of perioperative camrelizumab combined with apatinib in patients with resectable high\u2010risk HCC. In this single\u2010arm, phase II study, 31 patients with resectable HCC and high recurrence risk factors (e.g., large tumor size, multinodularity, and vascular invasion) received neoadjuvant camrelizumab (200\u00a0mg every 2 weeks) and apatinib (250\u00a0mg daily) for four cycles, followed by surgical resection and adjuvant therapy with the same regimen for up to 1 year. The primary endpoint was major pathological response (MPR), defined as \u2264 50% viable tumor cells in resected specimens. A total of 31 patients were enrolled in the study. Among 26 patients who underwent surgery, the MPR rate was 46.2%. The median disease\u2010free survival (DFS) in patients who underwent surgery was 24.1 months (95% confidence interval [CI]: 14.4\u2013not estimable [NE]). The median progression\u2010free survival (PFS) in all patients was 18.3 months (95% CI: 11.6\u2013NE). In the neoadjuvant setting, Grade 3 or higher adverse events were observed in 12.9% of patients. Perioperative camrelizumab combined with apatinib demonstrated promising efficacy and manageable safety in high\u2010risk resectable HCC.<\/jats:p>","DOI":"10.1002\/mco2.70861","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:49:21Z","timestamp":1791899361000},"source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Camrelizumab and Apatinib for High\u2010Risk Resectable Hepatocellular Carcinoma: A Phase II Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Yunlong","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Tumors Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Tumors Tianjin Medical University Cancer Institute and Hospital  Tianjin 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