{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:55:42Z","timestamp":1793141742618,"version":"4.5.0"},"reference-count":426,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373674"],"award-info":[{"award-number":["82373674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M753641"],"award-info":[{"award-number":["2024M753641"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sirtuins (SIRT1\u2013SIRT7) are nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) dependent deacylases that serves as metabolic sensors,\u00a0coupling cellular energy status to chromatin structure, mitochondrial function, and stress responses. Dysregulated SIRT activity has been extensively studied in aging, metabolic syndrome, cardiovascular disease, neurodegeneration, cancer, and immune disorders. However, robust human evidence and SIRT\u2010targeted therapies are lacking. Transgenic mouse models serve as key platforms to study gene function and guide therapeutic development. This review synthesizes evidence from\n                    <jats:italic>Sirt1\u20137<\/jats:italic>\n                    transgenic mouse models regarding the core cellular processes governed by SIRTs: metabolism, genome integrity, stress resistance, immunity, and autophagy, and illustrates their operation across different organ systems. By comparing global, tissue\u2010specific, and inducible knockout (KO) and overexpression (OE) models of cardiovascular, respiratory, digestive, nervous, endocrine, urogenital, musculoskeletal, malignant, and immune diseases, we identified central regulatory SIRTs (SIRT1, SIRT3, and SIRT6), context\u2010dependent modifiers (SIRT2, SIRT4, SIRT5, and SIRT7), and their organ\u2010 and cell type\u2010specific functions. We also summarize representative small\u2010molecule SIRT activators, inhibitors, and degraders, covering both clinical and preclinical studies, and highlight where contradictions and knowledge gaps remain. Together, these analyses help clarify which aspects of SIRT modulation are most promising and under what isoform, tissue, and disease contexts they should be pursued for the development of SIRT\u2011targeted therapies in human disease.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70866","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:02:02Z","timestamp":1784728922000},"source":"Crossref","is-referenced-by-count":2,"title":["SIRT Family: Biological Functions and Therapeutic Targets"],"prefix":"10.1002","volume":"7","author":[{"given":"Jia\u2010Yi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Liaoning Institute of Birth Health and Development Reproductive Hospital of China Medical University  Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"You","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center Affiliated Cancer Hospital of University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health China Medical University  Shenyang China"},{"name":"Key Laboratory of Environmental Stress and Chronic Disease Control &amp; Prevention Ministry of Education China Medical University  Shenyang China"},{"name":"NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University) National Health Commission  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan\u2010Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Shengjing Hospital of China Medical University  Shenyang China"},{"name":"Department of Oncology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ting","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Liaoning Institute of Birth Health and Development Reproductive Hospital of China Medical University  Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3000"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.19.2570"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2010.0677"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070140"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00373J"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014537"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3327"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08529"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01701-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.03.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1207861"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2018.1458071"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.218990"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12038"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12235"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz2590"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314597"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01257-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00335.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.1.38-54.2003"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934713100"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-193979"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-243568"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313865"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46243"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0616"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2946-5"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2912-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208634"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23366"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1810"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111308108"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800612"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00057.2018"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12930"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315767"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.003"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0339"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.03.088"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14961"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00425"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.057"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00170.2020"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100616"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00087-13"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.047"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep02806"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.01.081"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.026"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.09.037"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101723"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100062"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.168039"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.11.044"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10815"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00544.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4542-6"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00664-1"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166249"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706945114"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.007"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.164558"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.006"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.09.001"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.124404"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3172"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.008"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02713"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.211342.112"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.004"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136856"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601077R"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00832.2015"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44688"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30421"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.525949"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201745124"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.033"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26413"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00350-6"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-021-00240-1"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593499"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102310"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15327"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.247"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88725"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113914"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.05.026"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010146"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1810"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00443-x"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13204"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12101428"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11040706"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.008547"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy036"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310933"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14332"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03140-20"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2020.1809961"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1690-5"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6859"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39618"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5091"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.753501"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-021-09649-2"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06537-5"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111479"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121949"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06216-x"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13811"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101538"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx048"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308895"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07622"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.05.022"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.035"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102615"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101493"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203104"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008319"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500326"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124710"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103573"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05567-8"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa042"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0114-1"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109876"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9050409"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120722"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.04.006"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02341"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.005"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.05.012"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005309"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091477"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.10.021"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052573"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24257-7"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.10.025"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.026"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.138"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712145105"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41376"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01526"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9110369"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02573-9"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13429"},{"key":"e_1_2_11_151_1","first-page":"3517","article-title":"Sirt3 Deficiency Exacerbates P53\/Parkin\u2011Mediated Mitophagy Inhibition and Promotes Mitochondrial Dysfunction: Implication for Aged Hearts","volume":"41","author":"Li Y.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001494R"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130414"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29229"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9951-x"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6662"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-020-09857-w"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014821"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.023"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.01.001"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00418.2009"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.05.012"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803790105"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01636-07"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509217"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14044"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1228"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001715"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2648946"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201386907"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125151"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.123.012452"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205005"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000267723.65696.4a"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020426"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2018.7703"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-015-0493-6"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211796"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00454.2014"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.07.019"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000915"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.04.030"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2961"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13357"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy033"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00676.2015"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.092"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.03.017"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.687559"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313865"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2024.05.003"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114839"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104863"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103322"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq107"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309354110"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn224"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.118778"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad381"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz712"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202176"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111744"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107926"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002384"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1111-4"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006114"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16661"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2024.117483"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.07.032"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314032"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01456-x"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-025-01628-1"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.435107"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243592"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10070996"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.05.013"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60132"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaj1789"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204628"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.135103"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.059"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119997"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01667149"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0069-8"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.06.001"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75615-3"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.09.018"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.11.015"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.270"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28777"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137566"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117477"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26051807"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.05.002"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.01.004"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2017.00085"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1402834"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.03.021"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00184"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.04.001"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00311-0"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6403"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx100"},{"key":"e_1_2_11_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.12.035"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0027-10.2010"},{"key":"e_1_2_11_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111062"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1446-19.2019"},{"key":"e_1_2_11_248_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2558"},{"key":"e_1_2_11_249_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034805"},{"key":"e_1_2_11_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0352-1"},{"key":"e_1_2_11_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.11.012"},{"key":"e_1_2_11_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110702"},{"key":"e_1_2_11_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.054"},{"key":"e_1_2_11_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2024.03.017"},{"key":"e_1_2_11_255_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.13.9.27"},{"key":"e_1_2_11_256_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06748-w"},{"key":"e_1_2_11_257_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05435-w"},{"key":"e_1_2_11_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109345"},{"key":"e_1_2_11_259_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adl6441"},{"key":"e_1_2_11_260_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00122.2017"},{"key":"e_1_2_11_261_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11223609"},{"key":"e_1_2_11_262_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35219-z"},{"key":"e_1_2_11_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.02.006"},{"key":"e_1_2_11_264_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08778"},{"key":"e_1_2_11_265_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016040385"},{"key":"e_1_2_11_266_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030226"},{"key":"e_1_2_11_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112861"},{"key":"e_1_2_11_268_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33201"},{"key":"e_1_2_11_269_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13362"},{"key":"e_1_2_11_270_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00937-2"},{"key":"e_1_2_11_271_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019020163"},{"key":"e_1_2_11_272_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3363"},{"key":"e_1_2_11_273_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00255.2017"},{"key":"e_1_2_11_274_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013010069"},{"key":"e_1_2_11_275_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45003"},{"key":"e_1_2_11_276_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI150051"},{"key":"e_1_2_11_277_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13491"},{"key":"e_1_2_11_278_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.147074"},{"key":"e_1_2_11_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.12.002"},{"key":"e_1_2_11_280_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1632"},{"key":"e_1_2_11_281_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000153R"},{"key":"e_1_2_11_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.06.006"},{"key":"e_1_2_11_283_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-05043-9"},{"key":"e_1_2_11_284_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3677"},{"key":"e_1_2_11_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115361"},{"key":"e_1_2_11_286_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146728"},{"key":"e_1_2_11_287_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2024.102012"},{"key":"e_1_2_11_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115497"},{"key":"e_1_2_11_289_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0306-9"},{"key":"e_1_2_11_290_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2116855119"},{"key":"e_1_2_11_291_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37750"},{"key":"e_1_2_11_292_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12776"},{"key":"e_1_2_11_293_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12437"},{"key":"e_1_2_11_294_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10838-5"},{"key":"e_1_2_11_295_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.49735"},{"key":"e_1_2_11_296_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01637-w"},{"key":"e_1_2_11_297_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045331"},{"key":"e_1_2_11_298_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-01993-1"},{"key":"e_1_2_11_299_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11013"},{"key":"e_1_2_11_300_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138926"},{"key":"e_1_2_11_301_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02071-w"},{"key":"e_1_2_11_302_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127080"},{"key":"e_1_2_11_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.05.002"},{"key":"e_1_2_11_304_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.527531"},{"key":"e_1_2_11_305_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI151803"},{"key":"e_1_2_11_306_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132378"},{"key":"e_1_2_11_307_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00874-1"},{"key":"e_1_2_11_308_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-863233"},{"key":"e_1_2_11_309_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800148"},{"key":"e_1_2_11_310_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01037"},{"key":"e_1_2_11_311_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1238858"},{"key":"e_1_2_11_312_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.566349"},{"key":"e_1_2_11_313_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1582743"},{"key":"e_1_2_11_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33311-1"},{"key":"e_1_2_11_315_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201706-1094LE"},{"key":"e_1_2_11_316_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4710"},{"key":"e_1_2_11_317_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.65"},{"key":"e_1_2_11_318_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0237"},{"key":"e_1_2_11_319_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31822578db"},{"key":"e_1_2_11_320_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02104-8"},{"key":"e_1_2_11_321_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2016.02.004"},{"key":"e_1_2_11_322_1","first-page":"88","article-title":"Sirtuin 1 Signaling and Alcoholic Fatty Liver Disease","volume":"4","author":"You M.","year":"2015","journal-title":"Hepatobiliary Surgery and Nutrition"},{"key":"e_1_2_11_323_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01854"},{"key":"e_1_2_11_324_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i5.1238"},{"key":"e_1_2_11_325_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.063"},{"key":"e_1_2_11_326_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202884"},{"key":"e_1_2_11_327_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S310990"},{"key":"e_1_2_11_328_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0237-7"},{"key":"e_1_2_11_329_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.03.001"},{"key":"e_1_2_11_330_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0238-6"},{"key":"e_1_2_11_331_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0235-9"},{"key":"e_1_2_11_332_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02484-0"},{"key":"e_1_2_11_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.05.036"},{"key":"e_1_2_11_334_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-017-0032-2"},{"key":"e_1_2_11_335_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(11)70065-7"},{"key":"e_1_2_11_336_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1507-8"},{"key":"e_1_2_11_337_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.016"},{"key":"e_1_2_11_338_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_11_339_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_11_340_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2017.07.001"},{"key":"e_1_2_11_341_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25628"},{"key":"e_1_2_11_342_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70197-7"},{"key":"e_1_2_11_343_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.07.008"},{"key":"e_1_2_11_344_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab367"},{"key":"e_1_2_11_345_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.40"},{"key":"e_1_2_11_346_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.09.001"},{"key":"e_1_2_11_347_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01095-9"},{"key":"e_1_2_11_348_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02144-6"},{"key":"e_1_2_11_349_1","first-page":"33","article-title":"Sirt1 Protects Against Hippocampal Atrophy and Its Induced Cognitive Impairment in Middle\u2010Aged Mice","volume":"23","author":"Sun Z.","year":"2022","journal-title":"BMC Neuroscience [Electronic Resource]"},{"key":"e_1_2_11_350_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12765"},{"key":"e_1_2_11_351_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.01.016"},{"key":"e_1_2_11_352_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.57.102904.190118"},{"key":"e_1_2_11_353_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.08.060"},{"key":"e_1_2_11_354_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_11_355_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00499-w"},{"key":"e_1_2_11_356_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061340"},{"key":"e_1_2_11_357_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0335-y"},{"key":"e_1_2_11_358_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.183"},{"key":"e_1_2_11_359_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05486"},{"key":"e_1_2_11_360_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-S005"},{"key":"e_1_2_11_361_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.236"},{"key":"e_1_2_11_362_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306273"},{"key":"e_1_2_11_363_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00724"},{"key":"e_1_2_11_364_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.12.001"},{"key":"e_1_2_11_365_1","first-page":"154","article-title":"Cholesterol and Cardiovascular Disease in the Elderly. Facts and Gaps","volume":"4","author":"Felix\u2010Redondo F. J.","year":"2013","journal-title":"Aging Disease"},{"key":"e_1_2_11_366_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-025-01109-3"},{"key":"e_1_2_11_367_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87759-x"},{"key":"e_1_2_11_368_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101097"},{"key":"e_1_2_11_369_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021121591"},{"key":"e_1_2_11_370_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.196"},{"key":"e_1_2_11_371_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.08.036"},{"key":"e_1_2_11_372_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201506020"},{"key":"e_1_2_11_373_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2015.05.002"},{"key":"e_1_2_11_374_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.047"},{"key":"e_1_2_11_375_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-021-00661-3"},{"key":"e_1_2_11_376_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.11.001"},{"key":"e_1_2_11_377_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217072"},{"key":"e_1_2_11_378_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.09.017"},{"key":"e_1_2_11_379_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276523"},{"key":"e_1_2_11_380_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00551-9"},{"key":"e_1_2_11_381_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-025-01903-2"},{"key":"e_1_2_11_382_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-24018-3"},{"key":"e_1_2_11_383_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes15111370"},{"key":"e_1_2_11_384_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010143"},{"key":"e_1_2_11_385_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06261"},{"key":"e_1_2_11_386_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000402"},{"key":"e_1_2_11_387_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.441816"},{"key":"e_1_2_11_388_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04429-5"},{"key":"e_1_2_11_389_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202501428R"},{"key":"e_1_2_11_390_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02268"},{"key":"e_1_2_11_391_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115878"},{"key":"e_1_2_11_392_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07959-5"},{"key":"e_1_2_11_393_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17915"},{"key":"e_1_2_11_394_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224385"},{"key":"e_1_2_11_395_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.032"},{"key":"e_1_2_11_396_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.297"},{"key":"e_1_2_11_397_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12512"},{"key":"e_1_2_11_398_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adv0766"},{"key":"e_1_2_11_399_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319833121"},{"key":"e_1_2_11_400_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6480"},{"key":"e_1_2_11_401_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00191"},{"key":"e_1_2_11_402_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.02.007"},{"key":"e_1_2_11_403_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051126"},{"key":"e_1_2_11_404_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-20-0168"},{"key":"e_1_2_11_405_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01223"},{"key":"e_1_2_11_406_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44179-x"},{"key":"e_1_2_11_407_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06018-1"},{"key":"e_1_2_11_408_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.11.120"},{"key":"e_1_2_11_409_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2022.27.1.37"},{"key":"e_1_2_11_410_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00633-8"},{"key":"e_1_2_11_411_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-020-1096-3"},{"key":"e_1_2_11_412_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.9617"},{"key":"e_1_2_11_413_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-018-0297-4"},{"key":"e_1_2_11_414_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2017.0146"},{"key":"e_1_2_11_415_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4252"},{"key":"e_1_2_11_416_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2017.1392264"},{"key":"e_1_2_11_417_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-017-1097-4"},{"key":"e_1_2_11_418_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.03.007"},{"key":"e_1_2_11_419_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113824"},{"key":"e_1_2_11_420_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.11.013"},{"key":"e_1_2_11_421_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6580"},{"key":"e_1_2_11_422_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01166H"},{"key":"e_1_2_11_423_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2021.03.004"},{"key":"e_1_2_11_424_1","doi-asserted-by":"publisher","DOI":"10.7762\/cnr.2020.9.4.284"},{"key":"e_1_2_11_425_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.02259"},{"key":"e_1_2_11_426_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000597"},{"key":"e_1_2_11_427_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-485441"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:53:04Z","timestamp":1787122384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":426,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/mco2.70866"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70866","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"e70866"}}