{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:08:52Z","timestamp":1790060932601,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SCU2024D017\/SCU2025D017"],"award-info":[{"award-number":["SCU2024D017\/SCU2025D017"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC1909"],"award-info":[{"award-number":["2024NSFSC1909"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Small cell lung cancer (SCLC) is a highly malignant tumor characterized by strong invasiveness and poor prognosis. Immune checkpoint inhibitors have provided new therapeutic options for SCLC, but their comparative clinical benefit remains unclear. This retrospective study enrolled 171 patients with SCLC treated between January 2016 and June 2023, with follow\u2010up through June 30, 2024, to compare survival and safety profiles between anti\u2010programmed death\u20101 (anti\u2010PD\u20101) and anti\u2010programmed death\u2010ligand 1 (anti\u2010PD\u2010L1) inhibitors. Among the 119 patients (69.6%) who received immunotherapy plus chemoradiotherapy, the median overall survival (OS) was 48.3 months, compared with 25.2 months in those who did not receive radiotherapy. Multivariable Cox regression confirmed that liver metastasis and radiotherapy status were independently associated with OS and progression\u2010free survival (PFS). Subgroup analyses revealed that patients younger than 65 years who underwent radiotherapy, particularly those without liver metastasis, achieved longer OS with anti\u2010PD\u20101 agents. In conclusion, both anti\u2010PD\u20101 and anti\u2010PD\u2010L1 inhibitors improved the prognosis of SCLC. Patients younger than 65 years receiving radiotherapy and those with limited\u2010stage SCLC may represent populations more likely to benefit from anti\u2010PD\u20101 therapy.<\/jats:p>","DOI":"10.1002\/mco2.70872","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:44:57Z","timestamp":1789195497000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunotherapy With Anti\u2010PD\u20101\u00a0Versus Anti\u2010PD\u2010L1 in SCLC: A Comprehensive Retrospective Analysis"],"prefix":"10.1002","volume":"7","author":[{"given":"Ruiyuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1199-7656","authenticated-orcid":false,"given":"Jiadi","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital  Chengdu Sichuan China"},{"name":"Institute of Respiratory Health, Frontiers Science Center for Disease\u2010Related Molecular Network West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"The Research Units of West China Chinese Academy of Medical Sciences, West China Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0011"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.03.207"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.09.031"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2017.58.6.1111"},{"issue":"3","key":"e_1_2_12_6_1","first-page":"292","article-title":"Which Patients With Extensive Stage Small\u2010Cell Lung Cancer Should and Should Not Receive Thoracic Radiotherapy?","volume":"4","author":"Slotman B. 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