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Recent evidence indicates that protein homeostasis (proteostasis) functions as a crucial molecular link connecting tumor progression, therapeutic resistance, cardiac remodeling, and treatment\u2010related cardiotoxicity. Proteostasis, which encompasses the cellular processes of protein synthesis, folding, quality control, and degradation, dictates tissue adaptation to chronic stress. Notably, the adaptive mechanisms that allow tumor cells to endure proteotoxic stress and resist therapy are often vital for maintaining cardiac structure and function. Thus, tumor control and cardiovascular injury may be divergent outcomes of a common stress\u2013response framework. In this review, we propose proteostasis as a comprehensive framework for understanding the cancer\u2013cardiovascular interface. We analyze how the ubiquitin\u2013proteasome system, autophagy\u2013lysosome pathway, endoplasmic reticulum stress\u2010induced unfolded protein response signaling, and molecular chaperone networks are differentially reconfigured in cancer and cardiac tissues, influencing tumor survival, therapeutic susceptibility, and cardiovascular dysfunction. Additionally, we explore the translational implications of proteostasis dysregulation, including mechanisms of anticancer therapy\u2010induced cardiotoxicity, emerging biomarkers, cardioprotective strategies, and opportunities for precision cardio\u2010oncology. By conceptualizing efficacy and toxicity as interconnected outcomes of shared proteostasis biology, this review establishes a foundation for developing therapies that optimize cancer control while safeguarding cardiovascular health.<\/jats:p>","DOI":"10.1002\/mco2.70892","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:40:37Z","timestamp":1786156837000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities"],"prefix":"10.1002","volume":"7","author":[{"given":"Jacob Eli","family":"Garc\u00eda Torres","sequence":"first","affiliation":[{"name":"Department of Cardiology Angiology and Pneumology University Hospital Heidelberg  Heidelberg Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Cardiology Angiology and Pneumology University Hospital Heidelberg  Heidelberg Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-9754","authenticated-orcid":false,"given":"Ashraf Yusuf","family":"Rangrez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Angiology and Pneumology University Hospital Heidelberg  Heidelberg Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01017-x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020406"},{"key":"e_1_2_13_4_1","first-page":"192","article-title":"Cancer Risk Subsequent to Cardiovascular Disease: A Prospective Population\u2010Based Study and Meta\u2010Analysis","volume":"23","author":"Shu C.","year":"2025","journal-title":"BMC Medicine [Electronic 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