{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:08:35Z","timestamp":1790060915903,"version":"4.0.1"},"reference-count":390,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270746"],"award-info":[{"award-number":["32270746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203415"],"award-info":[{"award-number":["82203415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372668"],"award-info":[{"award-number":["82372668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ24H160004"],"award-info":[{"award-number":["LZ24H160004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS26H160001"],"award-info":[{"award-number":["LMS26H160001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFE0107800"],"award-info":[{"award-number":["2022YFE0107800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102025\u201000101"],"award-info":[{"award-number":["226\u20102025\u201000101"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cyclins and cyclin\u2010dependent kinases (CDKs) are frequently dysregulated in human cancers and represent compelling therapeutic targets. Beyond their well\u2010recognized roles in cell cycle control, CDK\/cyclin complexes orchestrate diverse oncogenic processes, including transcription, genome maintenance, epigenetics, metabolism, and immune regulation. Deciphering the multifaceted biology of CDK\/cyclin will provide valuable insights and rationales for the development of CDK\/cyclin\u2010targeting strategies and modalities. While the clinical success of CDK4\/6 inhibitors has validated CDKs as druggable targets, further efforts are urgently needed to target other CDKs and cyclins. This review critically evaluates recent mechanistic advances in CDK\/cyclin biology and their pathological dysregulation across malignancies. We analyze the paradigm shift from conventional enzymatic inhibition toward proximity\u2010induced modulation. Specifically, we highlight emerging approaches including proteolysis\u2010targeting chimeras, HSP90\u2010mediated targeting chimeras, hydrophobic tagging, molecular glues, and autophagy\u2010tethering compounds that achieve selective elimination of CDKs or their cyclin partners. In parallel, we summarize strategies designed to redistribute CDK complexes and rewire transcription without enzymatic ablation, referred to as chemical inducers of proximity and transcriptional\/epigenetic modulators. By integrating fundamental CDK\/cyclin biology with pharmacological innovation in targeted protein degradation and kinase reprogramming, this review provides a timely roadmap for the CDK\/cyclin research field and expands the frontiers of CDK\/cyclin\u2010targeted cancer therapy.<\/jats:p>","DOI":"10.1002\/mco2.70898","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:14:05Z","timestamp":1786943645000},"source":"Crossref","is-referenced-by-count":0,"title":["Cyclins and Cyclin\u2010Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Suya","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology (Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education) The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Neurosurgery Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center For Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Pediatric Cancer Research Center National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center For Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Pediatric Cancer Research Center National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center For Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Pediatric Cancer Research Center National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingze","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry College of Life Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center For Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Pediatric Cancer Research Center National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center For Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Pediatric Cancer Research Center National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education) The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Provincial Clinical Research Center For Cancer  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatric Cancer Research Center National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Department of Orthopedic Surgery Children's Hospital Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center For Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Pediatric Cancer Research Center National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases  Hangzhou China"},{"name":"Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education) The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Biochemistry College of Life Sciences Zhejiang University  Hangzhou China"},{"name":"Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5542.502"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03262-7"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-023-1027-5"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0563-4"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0528"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188716"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0300-y"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1816"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.27"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00411-8"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2026.0318"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00172-9"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02475-6"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2025.2092"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56096-2"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00840-4"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl5361"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2500021"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.04.021"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112139"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180112"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.09.002"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62765-z"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.12.6623"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4505"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2011.02.016"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2025.12.007"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/376313a0"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0896-696"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adw0053"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E22-06-0196"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06046"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7769"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2024.04.012"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.04.026"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1290631"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd4484"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46375-9"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2106"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.04.012"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-70778-5"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-022-00494-y"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50891-z"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CB00201A"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004088"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2128"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.034"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn7625"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1107"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1515\/medgen-2024-2006"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04798-8"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.03.012"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607279200"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01785-w"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04698-x"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.09.024"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205873"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03641-y"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46358-w"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-023-00407-7"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02468-8"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1494"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.774845"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0954"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04638-9"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.05.013"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.11.011"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.32.22296"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.24.10542-10557.2004"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-21-0806"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abm5011"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.36401\/JIPO-24-22"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00300-9"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2965"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106249"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/10985549.2023.2273193"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3046"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710119"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3125"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202145"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6875"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90101-4"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90100-D"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90042-W"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.3.331"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.09.009"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.068"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06274-3"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi2421"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23465"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36892-4"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104010"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05412-x"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.053"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-0433"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22797"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07434-1"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101602"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111697"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.07.012"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.12.002"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23903"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001347"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.341545.120"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.063"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00926-x"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.024"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.019"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.05.007"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.11.003"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0461"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.02.012"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116613"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01171"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad538"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09590"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.058"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.100197.3"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14904"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01512-5"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092181"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01230"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0238"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113091"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.013"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.051"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2023.2219470"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02892-3"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107876"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abp9005"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2019.05.001"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4730"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/21541264.2018.1523668"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20224"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.05.092"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-024-02982-w"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.210381"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306814110"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1147632"},{"key":"e_1_2_14_142_1","first-page":"3992","article-title":"The Cdc\u20102\u2010related Kinase, PISSLRE, Is Essential for Cell Growth and Acts in G2 Phase of the Cell Cycle","volume":"55","author":"Li S.","year":"1995","journal-title":"Cancer Research"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06842"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23636"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.01.022"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2011.1617"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09845-w"},{"key":"e_1_2_14_148_1","first-page":"1165","article-title":"Cyclin\u2011Dependent Kinase 10 Prevents Glioma Metastasis via Modulation of Snail Expression","volume":"18","author":"Li H.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.001"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-015-0246-4"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.548"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80239-7"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03436-3"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.007963"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170815102036"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1201"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.09.027"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.04.016"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E23-08-0303"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0406-8"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.08.001"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf1343"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2023114051"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210057200"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-71119-2"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255044"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1157"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-14-2"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph12020050"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1577665"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22745"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.040"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202500882"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw8412"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010277"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2022.10.003"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114433"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf8698"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105030"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz5041"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-0222"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09703-y"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0758-y"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.09.004"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.12.009"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI193745"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0442-9"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.19.00383"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1678"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30375-8"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1109-1275"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00774-y"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123259"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37978"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-02-0125"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.08.009"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-021-00372-5"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411733"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvr.2026.200339"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aae0477"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2112674118"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101148"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-007529"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2023220"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084011"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060860"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07888-x"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2025.13547"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.11.035"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-025-00414-1"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1829"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.01.031"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00605-6"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-024-00138-7"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2024.101054"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00615.2012"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12001-2"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0952-5"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1297-6"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50275-0"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607234200"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13962"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112316"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3916"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503223"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712306105"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4663"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00023"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13438"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02292-4"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.499"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08387-1"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111331"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00312-4"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-015-0639-x"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.04.019"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.02.015"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.11.105"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447632"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07339-3"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111331"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123148"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00828-6"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.05.070"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01283"},{"key":"e_1_2_14_246_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06261-11"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-019-00076-x"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005485"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150486"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160941"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14812-0"},{"key":"e_1_2_14_252_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01017-14"},{"key":"e_1_2_14_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110032"},{"key":"e_1_2_14_254_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.258831"},{"key":"e_1_2_14_255_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2699"},{"key":"e_1_2_14_256_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13046-022-02362-w","article-title":"CDK16 promotes the Progression and Metastasis of Triple\u2010negative Breast Cancer by Phosphorylating PRC1","volume":"41","author":"Li X.","year":"2022","journal-title":"Journal of Experimental & Clinical Cancer Research: CR"},{"key":"e_1_2_14_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.03.012"},{"key":"e_1_2_14_258_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-03408-z"},{"key":"e_1_2_14_259_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12152"},{"key":"e_1_2_14_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.080"},{"key":"e_1_2_14_261_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119404"},{"key":"e_1_2_14_262_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202401192"},{"key":"e_1_2_14_263_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210008"},{"key":"e_1_2_14_264_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2016.40"},{"key":"e_1_2_14_265_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw615"},{"key":"e_1_2_14_266_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10993-5"},{"key":"e_1_2_14_267_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45545"},{"key":"e_1_2_14_268_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15625"},{"key":"e_1_2_14_269_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-019-00376-7"},{"key":"e_1_2_14_270_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02043-6"},{"key":"e_1_2_14_271_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666210329122147"},{"key":"e_1_2_14_272_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01455.x"},{"key":"e_1_2_14_273_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309995200"},{"key":"e_1_2_14_274_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.5.2541"},{"key":"e_1_2_14_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.10.003"},{"key":"e_1_2_14_276_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14171341"},{"key":"e_1_2_14_277_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.34430"},{"key":"e_1_2_14_278_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07402-8"},{"key":"e_1_2_14_279_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm011"},{"key":"e_1_2_14_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107626"},{"key":"e_1_2_14_281_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22113-2"},{"key":"e_1_2_14_282_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC05709C"},{"key":"e_1_2_14_283_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314032"},{"key":"e_1_2_14_284_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2013.80"},{"key":"e_1_2_14_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.040"},{"key":"e_1_2_14_286_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.161"},{"key":"e_1_2_14_287_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006912"},{"key":"e_1_2_14_288_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45967"},{"key":"e_1_2_14_289_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.290"},{"key":"e_1_2_14_290_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.12.025"},{"key":"e_1_2_14_291_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3265"},{"key":"e_1_2_14_292_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555220965528"},{"key":"e_1_2_14_293_1","first-page":"933","article-title":"Chemically Induced Cellular Proteolysis: an Emerging Therapeutic Strategy for Undruggable Targets","volume":"41","author":"Moon S.","year":"2018","journal-title":"Molecules and Cells"},{"key":"e_1_2_14_294_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.31"},{"key":"e_1_2_14_295_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"e_1_2_14_296_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00736-3"},{"key":"e_1_2_14_297_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215506"},{"key":"e_1_2_14_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.11.006"},{"key":"e_1_2_14_299_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00871"},{"key":"e_1_2_14_300_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201901336"},{"key":"e_1_2_14_301_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00742-5"},{"key":"e_1_2_14_302_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01160"},{"key":"e_1_2_14_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113849"},{"key":"e_1_2_14_304_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-026-02925-2"},{"key":"e_1_2_14_305_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00011"},{"key":"e_1_2_14_306_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2538"},{"key":"e_1_2_14_307_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01350"},{"key":"e_1_2_14_308_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01621"},{"key":"e_1_2_14_309_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01111"},{"key":"e_1_2_14_310_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70723"},{"key":"e_1_2_14_311_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202523088"},{"key":"e_1_2_14_312_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00765-y"},{"key":"e_1_2_14_313_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00174-z"},{"key":"e_1_2_14_314_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1726"},{"key":"e_1_2_14_315_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00384"},{"key":"e_1_2_14_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101752"},{"key":"e_1_2_14_317_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01596"},{"key":"e_1_2_14_318_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111952"},{"key":"e_1_2_14_319_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00965"},{"key":"e_1_2_14_320_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00965"},{"key":"e_1_2_14_321_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0369"},{"key":"e_1_2_14_322_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1390"},{"key":"e_1_2_14_323_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00925"},{"key":"e_1_2_14_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112903"},{"key":"e_1_2_14_325_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2374-x"},{"key":"e_1_2_14_326_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01754-x"},{"key":"e_1_2_14_327_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01409-z"},{"key":"e_1_2_14_328_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59994"},{"key":"e_1_2_14_329_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109394"},{"key":"e_1_2_14_330_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0594-x"},{"key":"e_1_2_14_331_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.10.007"},{"key":"e_1_2_14_332_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2026-6778"},{"key":"e_1_2_14_333_1","unstructured":"R.Andreas R.Thomas M.Laura et\u00a0al. \u201cCompounds that mediate protein degradation and methods of use thereof\u201d WO Patent WO\u20102024092039\u2010A1 filed Oct 25 2023."},{"key":"e_1_2_14_334_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01648"},{"key":"e_1_2_14_335_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.853993"},{"key":"e_1_2_14_336_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00257"},{"key":"e_1_2_14_337_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300769"},{"key":"e_1_2_14_338_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.03.047"},{"key":"e_1_2_14_339_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00828"},{"key":"e_1_2_14_340_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2400127"},{"key":"e_1_2_14_341_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13334-8"},{"key":"e_1_2_14_342_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.02.010"},{"key":"e_1_2_14_343_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07666-9"},{"key":"e_1_2_14_344_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi2421"},{"key":"e_1_2_14_345_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02452-z"},{"key":"e_1_2_14_346_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109013"},{"key":"e_1_2_14_347_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2017.1295177"},{"key":"e_1_2_14_348_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-025-03897-6"},{"key":"e_1_2_14_349_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0758-y"},{"key":"e_1_2_14_350_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz5041"},{"key":"e_1_2_14_351_1","first-page":"23","article-title":"Future of PARP Inhibitors in Cancer Treatment: Overcoming Resistance and Enhancing Efficacy with Combination Therapies","volume":"27","author":"Shoaib M.","year":"2025","journal-title":"Journal of Zhejiang University Science B"},{"key":"e_1_2_14_352_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01459-w"},{"key":"e_1_2_14_353_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2300492"},{"key":"e_1_2_14_354_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-2428"},{"key":"e_1_2_14_355_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.256313"},{"key":"e_1_2_14_356_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.02.006"},{"key":"e_1_2_14_357_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102086"},{"key":"e_1_2_14_358_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1472407"},{"key":"e_1_2_14_359_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.02.006"},{"key":"e_1_2_14_360_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40244-7"},{"key":"e_1_2_14_361_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.1225"},{"key":"e_1_2_14_362_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117297"},{"key":"e_1_2_14_363_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.07.013"},{"key":"e_1_2_14_364_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.06.015"},{"key":"e_1_2_14_365_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01379-8"},{"key":"e_1_2_14_366_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42233-2"},{"key":"e_1_2_14_367_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108532"},{"key":"e_1_2_14_368_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02332"},{"key":"e_1_2_14_369_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.10.004"},{"key":"e_1_2_14_370_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202300413"},{"key":"e_1_2_14_371_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c01241"},{"key":"e_1_2_14_372_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62099-w"},{"key":"e_1_2_14_373_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63357-7"},{"key":"e_1_2_14_374_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44237-4"},{"key":"e_1_2_14_375_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118019"},{"key":"e_1_2_14_376_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03985-9"},{"key":"e_1_2_14_377_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.1c00500"},{"key":"e_1_2_14_378_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05499"},{"key":"e_1_2_14_379_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63928-8"},{"key":"e_1_2_14_380_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.057"},{"key":"e_1_2_14_381_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010025\u201002137\u20102"},{"key":"e_1_2_14_382_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00076"},{"key":"e_1_2_14_383_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2518248123"},{"key":"e_1_2_14_384_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-1129"},{"key":"e_1_2_14_385_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09257-z"},{"key":"e_1_2_14_386_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00534"},{"key":"e_1_2_14_387_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01177-2"},{"key":"e_1_2_14_388_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.11.009"},{"key":"e_1_2_14_389_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abn2707"},{"key":"e_1_2_14_390_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2322563121"},{"key":"e_1_2_14_391_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117773"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:51:28Z","timestamp":1790059888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,16]]},"references-count":390,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mco2.70898"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70898","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,16]]},"article-number":"e70898"}}