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Genome\u2010wide DNA methylation profiles in 48 healthy individuals were investigated after a 1\u2010month randomized isocaloric dietary intervention comparing effects of a VD versus a MR. Genome\u2010wide DNA methylation analysis revealed changes in differentially methylated positions following dietary intervention, with the VD group showing a higher degree of gene\u2010promoter silencing in cancer\u2010related pathways and cell growth\u2010associated pathways (mTOR and Hippo). Cell type deconvolution indicated an anti\u2010inflammatory shift in the VD group, characterized by decreased neutrophils and increased CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell proportions, aligning with whole blood count data. Pathway analysis reflected changes in gene promoter methylation consistent with macronutrient changes according to the diets, in that VD silenced lipid metabolism and increased insulin pathway genes. Interestingly, the health\u2010outcome\u2010trained epigenetic clocks PhenoAge and GrimAge indicated a deceleration of biological aging in the VD group, while the chronologically optimized Blood&amp;Skin clock showed an opposing acceleration. Convergent evidence from pathway analysis and health\u2010outcome epigenetic clocks thus suggests that a 1\u2010month VD drives epigenomic changes associated with reduced cancer risk and decelerated biological aging.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70899","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:43:31Z","timestamp":1785746611000},"source":"Crossref","is-referenced-by-count":0,"title":["A Vegan Diet Epigenetically Modulates Inflammatory Pathways and Biological Aging: Genome\u2010Wide DNA Methylation Analysis of a One\u2010Month Isocaloric Vegan Versus Meat\u2010Rich Dietary Intervention"],"prefix":"10.1002","volume":"7","author":[{"given":"L.","family":"Karbacher","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"},{"name":"Laboratory of Genetics The Salk Institute for Biological Studies  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-4121","authenticated-orcid":false,"given":"Jerome","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"},{"name":"Laboratory of Genetics The Salk Institute for Biological Studies  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kowarschik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Center for Complementary Medicine Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Lederer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Center for Complementary Medicine Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg Germany"},{"name":"Department of General Visceral and Transplantation Surgery University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ku","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine Faculty of Medicine Medical Center\u2010University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Center for Complementary Medicine Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg  Freiburg 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