{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:10:09Z","timestamp":1790061009923,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Solitary distant metastasis (SDM) is a distinct oligometastatic subtype associated with a relatively favorable prognosis. This multicenter retrospective study including 139 non\u2010small cell lung cancer (NSCLC) patients with SDM (2019\u20132024) was conducted to investigate prognostic factors for multiple metastases and identify the critical time window for local treatment. Statistical analyses included Cox regression, Kaplan\u2013Meier survival analysis, and restricted mean survival time (RMST). Results showed that driver gene status, tumor staging, systemic therapy, and local treatment were significantly associated with progression\u2010free survival (PFS). Notably, only early local treatment significantly delayed the onset of multiple metastases (hazard ratio [HR] = 0.55, 95% confidence interval [CI]: 0.30\u20130.99,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.05), prolonging the median time to multiple metastases by nearly 14 months (36.4\u00a0vs. 22.6 months). Kaplan\u2013Meier and RMST analyses revealed no distinct plateau phase, indicating the absence of an absolute temporal cutoff between \u201ctrue oligo\u2010metastasis\u201d and \u201ctransitional metastasis,\u201d which suggests that SDM in advanced NSCLC is an inherently indolent disease state. Using the maximum selected rank statistics method, an optimal cutoff of 138 days was identified to distinguish early from delayed local treatment, which requires further prospective validation.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70904","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:21:53Z","timestamp":1788355313000},"source":"Crossref","is-referenced-by-count":0,"title":["Early Local Treatment Delays Multiple Metastases in Non\u2010Small Cell Lung Cancer With Solitary Distant Metastasis: A Multicenter Retrospective Cohort Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Kang","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University  Beijing 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