{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:08:39Z","timestamp":1790060919140,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020440","name":"Beijing Health Promotion Association","doi-asserted-by":"publisher","award":["T2022\u2010ZX022"],"award-info":[{"award-number":["T2022\u2010ZX022"]}],"id":[{"id":"10.13039\/100020440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    LDL\u2010cholesterol (LDLC) to apolipoprotein B (ApoB) ratio is an accessible and reliable proxy for the LDL\u2010particle size. The aim of the present study was to investigate whether type 2 diabetes mellitus (T2DM) modulates the prognostic value of LDL\u2010C\/ApoB ratio in statin\u2010treated patients with coronary artery disease (CAD). The study included 21,382 patients with CAD who had received statin therapy at baseline with a median follow\u2010up of 3.1 years. The primary endpoint was major adverse cardiac events (MACE), including all\u2010cause mortality, non\u2010fatal myocardial infarction (MI), and ischemia\u2010driven revascularization. Higher LDL\u2010C\/ApoB level (\u22651.2) was associated with a decreased risk of MACE in the T2DM group (adjusted HR: 0.81, 95% CI: 0.69\u20130.96). A stepwise increase of 0.1 unit in LDL\u2010C\/ApoB ratio was associated with a 5% decrease for MACE only in the T2DM group. Among participants without T2DM, there was no clear association between LDL\u2010C\/ApoB and MACE (\n                    <jats:italic>p<\/jats:italic>\n                    for interaction &lt; 0.05). No significant association was identified between MACE risk and LDL\u2010C or ApoB in the T2DM group. Our data demonstrated that in CAD patients who had received statin therapy, LDL\u2010C\/ApoB ratio was related to adverse prognosis only in those with T2DM. Among patients with CAD and T2DM who are receiving statin treatment, LDL\u2010C\/ApoB may be a better indicator of residual cholesterol risk than LDL\u2010C.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70919","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:11:27Z","timestamp":1787728287000},"source":"Crossref","is-referenced-by-count":0,"title":["Type 2 Diabetes Mellitus Modifies the Prognostic Value of LDL Particle Size in Statin\u2010treated Patients With Coronary Artery Disease: A Large\u2010scale Cohort Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Xiaohui","family":"Bian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease  Beijing China"},{"name":"Cardiometabolic Medicine Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Department of Cardiology Fuwai Hospital National 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