{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:09:37Z","timestamp":1790060977473,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2026LSW057"],"award-info":[{"award-number":["ZR2026LSW057"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH549"],"award-info":[{"award-number":["ZR2024QH549"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The impact of immune checkpoint inhibitors combined with neoadjuvant chemotherapy (NAC) on surgical outcomes and immune remodeling remains underexplored. To investigate the efficacy and tumor immune microenvironment (TIME) changes of camrelizumab plus NAC for triple\u2010negative breast cancer (TNBC), we collected TNBC patients receiving neoadjuvant immunochemotherapy (NIC) or NAC from clinical trials and routine practice, and set a series of endpoints, including total pathological complete response (pCR), breast pCR and TIME characteristics. After propensity score matching, the NIC cohort showed significantly higher rates of total pCR, breast pCR, and axillary pCR, and a lower rate of axillary lymph node dissection than the NAC cohort (all\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Within the NIC group, patients achieving total pCR (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.012) or breast pCR (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0078) had superior disease\u2010free survival. Analysis of TIME characteristics indicated that the 7 TIME signatures, including tumor inflammation signature, antigen processing machinery and T cell\u2010related features, could predict pCR response to NIC. The finding suggested that in TNBC, NIC enhances pCR achievement and reduces axillary dissection risk. Elevated TIME profiles of the 7 signatures may predict favorable pCR response to NIC.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70924","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:04:39Z","timestamp":1786950279000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Efficacy of Neoadjuvant Camrelizumab Plus Chemotherapy for Triple\u2010Negative Breast Cancer and Tumor Immune Microenvironment Analysis: A Prospective\u2010Retrospective Cohort Study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-684X","authenticated-orcid":false,"given":"Yongsheng","family":"Wang","sequence":"first","affiliation":[{"name":"Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Qiu","sequence":"additional","affiliation":[{"name":"Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Wang","sequence":"additional","affiliation":[{"name":"Breast Disease Center Weifang People's Hospital Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1657-2955","authenticated-orcid":false,"given":"Xingchen","family":"Meng","sequence":"additional","affiliation":[{"name":"Breast Disease Center Weifang People's Hospital Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Breast Disease Center Weifang People's Hospital Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Weifang People's Hospital Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaopeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjian","family":"Wang","sequence":"additional","affiliation":[{"name":"Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjing","family":"Meng","sequence":"additional","affiliation":[{"name":"Toxicology Research Center Shandong Academy of Occupational Health and Occupational Medicine Shandong First Medical University &amp; 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