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Clinically, dysfunction of thalamo\u2010cortical circuits is shown to be profoundly implicated in a wide range of neurological and psychiatric diseases. Nevertheless, the neuroanatomical substrates governing these functions of the thalamus have rarely been directly mapped in humans. Here, we overviewed the acute responses of direct electrical stimulation (DES) delivered to the distributed thalamus sites in 52 epilepsy patients admitted for presurgical stereoelectroencephalography. Specifically, DES of the thalamus evoked a broad spectrum of in\u2010situ responses spanning fundamental functions such as sensory and motor processing, extending to complex neural operations encompassing neurovegetative regulation, cognitive processing, emotional modulation, and multimodal responsiveness. Moreover, through the integration of DES with functional human connectome (\n                    <jats:italic>n<\/jats:italic>\n                    = 1000), we found an intra\u2010thalamic intrinsic functional network associated with each specific clinical response. Our data provide direct substantiation for the complex functional architecture of the human thalamus, advancing current understanding of its role and potentially culminating in targeted therapeutic strategies tailored to ameliorate symptom\u2010specific neural circuit disorders.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70931","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:15:45Z","timestamp":1788354945000},"source":"Crossref","is-referenced-by-count":0,"title":["Unveiling Functional Architecture of Human Thalamus: AStereoelectroencephalography Study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-3068","authenticated-orcid":false,"given":"Liankun","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Clinical Research Center of Epilepsy Xuanwu Hospital Capital Medical University  Beijing 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