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Cardiomyocyte\u2010specific knockout of Ig\u03ba in mice results in reduced myocardial contraction, atrioventricular block (AV block), and even sudden death. Histological analysis revealed that Ig\u03ba knockout in cardiomyocytes leads to structural disorder of ICDs, dissemination of the cytoskeleton proteins desmin and F\u2010actin, as well as the loss of desmoplakin (DSP), N\u2010cadherin, and connexin 43 (Cx43) on ICDs. Mechanistically, Ig\u03ba can bind to and stabilize plectin, a cytoskeleton\u2010cross\u2010linking protein that facilitates the assembly of desmin\u2012actin networks that maintain normal cytoskeletal architecture. Ig\u03ba can also anchor desmin to the DSP through plectin, thereby stabilizing the integrity of the ICDs. This molecular interplay critically reinforces cardiomyocyte cohesion and maintains structural and functional homeostasises. Our findings are the first to identify cardiomyocyte\u2010expressed Ig\u03ba as a novel ICD\u2010related molecule that participates in cardiomyocyte contraction and conduction by stabilizing plectins. Importantly, this work extends current arrhythmogenic cardiomyopathy (ACM) pathogenic models by revealing that ablation of the non\u2010desmosomal gene Ig\u03ba disrupts ICD integrity, uncovering a new mechanism for non\u2010desmosomal gene\u2010related ACM and highlighting Ig\u03ba as a potential target for therapeutic investigations.<\/jats:p>","DOI":"10.1002\/mco2.70940","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:00:16Z","timestamp":1788951616000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity"],"prefix":"10.1002","volume":"7","author":[{"given":"Zhu","family":"Zhu","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Medical Immunology Peking University  Beijing China"},{"name":"Department of Immunology School of Basic Medical Sciences  Beijing 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