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Here, we investigated the role of methyltransferase\u2010like protein 7A (METTL7A) in\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>6<\/jats:sup>\n                    \u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A)\u2010mediated neutrophil activation and psoriasis pathogenesis. Using transcriptomic profiling of CXCR4\n                    <jats:sup>hi<\/jats:sup>\n                    neutrophils from psoriasis patients, m\n                    <jats:sup>6<\/jats:sup>\n                    A RNA immunoprecipitation, in vitro functional assays, and in vivo murine models of skin inflammation, along with genetic silencing and adoptive transfer experiments, we demonstrated that METTL7A was preferentially upregulated in pathogenic and aged CXCR4\n                    <jats:sup>hi<\/jats:sup>\n                    neutrophils and was positively associated with disease severity. METTL7A expression also increased during\u00a0human promyelocytic leukemia cells(HL\u201060 cell differentiation, maturation, and activation. Silencing\n                    <jats:italic>METTL7A<\/jats:italic>\n                    inhibited neutrophil maturation and aging, reduced NETosis, and alleviated psoriasiform inflammation in vivo. Adoptive transfer of\n                    <jats:italic>METTL7A<\/jats:italic>\n                    \u2010deficient neutrophils further protected mice from skin inflammation. Mechanistically, METTL7A stabilized phospholipid scramblase 1 (\n                    <jats:italic>PLSCR1<\/jats:italic>\n                    ) mRNA through m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010associated regulation, thereby enhancing reactive oxygen species production and neutrophil extracellular traps (NETs) formation. These findings identify METTL7A as a novel epitranscriptomic regulator of pathogenic CXCR4\n                    <jats:sup>hi<\/jats:sup>\n                    neutrophils, acting through the METTL7A\u2013PLSCR1 axis to drive NETosis and skin inflammation, thereby providing a rationale for developing m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010targeted therapies in neutrophil\u2010associated disorders.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70941","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:56:06Z","timestamp":1787036166000},"source":"Crossref","is-referenced-by-count":0,"title":["METTL7A\u2010Dependent m\n                    <sup>6<\/sup>\n                    A Methylation Orchestrates CXCR4\n                    <sup>hi<\/sup>\n                    Neutrophil Pathogenicity and NETosis in Skin Inflammation"],"prefix":"10.1002","volume":"7","author":[{"given":"Wanting","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkai","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an 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