{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:10:46Z","timestamp":1790061046343,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2706300"],"award-info":[{"award-number":["2023YFC2706300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long\u2010acting PEGylated recombinant human growth hormone (PEG\u2010rhGH) formulations have been developed to reduce injection frequency and improve adherence and quality of life. However, guidance on switching between short\u2010acting and long\u2010acting regimens during treatment and biomarker\u2010driven precision dose\u2010conversion strategies remains lacking in real\u2010world clinical practice. Therefore, this study analyzed data from two populations comprising healthy adult male subjects (\n                    <jats:italic>n<\/jats:italic>\n                    = 39) and pediatric patients with GHD (\n                    <jats:italic>n<\/jats:italic>\n                    = 408). The analysis used population pharmacokinetic (PopPK) and population pharmacokinetic\/pharmacodynamic (PopPK\/PD) models. The models showed adequate fit and external predictability. Biomarker\u2010clinical growth endpoint relationship analysis linked changes in insulin\u2010like growth factor\u20101 standard deviation score (IGF\u20101 SDS) to growth outcomes, and simulations assessed subgroup responses, missed\u2010dose scenarios, and IGF\u20101 SDS\u2010guided switching. Simulations enabled subgroup\u2010specific efficacy projections. Missed doses caused a greater loss of benefit with rhGH than with PEG\u2010rhGH. Switching simulations supported IGF\u20101 SDS\u2010guided conversion within accepted safety limits. The integrated framework provides concise, clinically interpretable rules for individualized titration, adherence\u2010aware care, and safer switching in pediatric GHD. This study supports precision dosing, missed\u2010dose management, and switching between daily rhGH and weekly PEG\u2010rhGH in pediatric GHD.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70945","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:08:13Z","timestamp":1787555293000},"source":"Crossref","is-referenced-by-count":0,"title":["Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone"],"prefix":"10.1002","volume":"7","author":[{"given":"Wei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Xiu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Genetics and Metabolism Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-199X","authenticated-orcid":false,"given":"Jie","family":"Mei","sequence":"additional","affiliation":[{"name":"Tianfu Jincheng Laboratory  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010qin","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases; Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u2010Hang","family":"Ju","sequence":"additional","affiliation":[{"name":"Institute of Big Data, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3632-636X","authenticated-orcid":false,"given":"Hui\u2010Xiang","family":"Tian","sequence":"additional","affiliation":[{"name":"Tianfu Jincheng Laboratory  Chengdu China"},{"name":"Department of Clinical Pharmacology Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology Third Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; 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