{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:46:12Z","timestamp":1792043172353,"version":"4.4.0"},"reference-count":204,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273092"],"award-info":[{"award-number":["82273092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ24H160006"],"award-info":[{"award-number":["LZ24H160006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY22H160001"],"award-info":[{"award-number":["LY22H160001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ22H160060"],"award-info":[{"award-number":["LQ22H160060"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY24H160011"],"award-info":[{"award-number":["LY24H160011"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>p62\/SQSTM1 is a multifunctional adaptor protein that serves as a central hub integrating cellular stress responses, including selective autophagy, antioxidant defense, metabolism, and immune signaling. Its diverse functions are precisely orchestrated by a complex network of posttranslational modifications (PTMs) that dynamically regulate its conformation, protein interactions, stability, and subcellular localization. This review provides a comprehensive overview of the p62 PTMs landscape, encompassing phosphorylation, ubiquitination, acetylation, methylation, and emerging cysteine\u2010based modifications. We first discuss how these PTMs coordinately maintain cellular homeostasis by fine\u2010tuning autophagic flux, activating antioxidant programs, coordinating nutrient sensing, preserving genomic stability, and regulating immune responses. We then examine how dysregulation of this PTMs network drives pathogenesis in major diseases including cancer, neurodegenerative disorders, metabolic diseases, and infections, with emphasis on context\u2010dependent molecular mechanisms. Furthermore, we summarize current preclinical evidence targeting p62 PTMs. Finally, we emphasize the critical need for advanced technologies to decipher PTMs crosstalk and dynamic regulation, coupled with the development of corresponding therapeutic strategies, to advance precision medicine. Understanding the p62 PTMs code offers promising opportunities for developing novel biomarkers and targeted therapies for human diseases.<\/jats:p>","DOI":"10.1002\/mco2.70949","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:04:13Z","timestamp":1790773453000},"source":"Crossref","is-referenced-by-count":0,"title":["Posttranslational Modifications of p62\/SQSTM1 in Health and Disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Weikai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Sugiarto","family":"Wijaya","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Zhejiang Key Laboratory of Multi\u2010omics Precision Diagnosis and Treatment of Liver Diseases School of Medicine Cancer Center of Zhejiang University Sir Run Run Shaw Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5991"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13718-w"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.06.038"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.06.020"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900441"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1967"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1813"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2012"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810611105"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2021"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.003"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00246-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.11.3044"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.259630"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.555441"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.003"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10059-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.039925"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.030"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b02038"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35795-8"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2017.11.3787"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/life15010126"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022113349"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115500"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111116"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7783"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv179"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.04.015"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.02.007"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.94789"},{"issue":"19","key":"e_1_2_12_33_1","first-page":"4576","article-title":"The Proteomic Analysis of Endogenous FAT10 Substrates Identifies p62\/SQSTM1 as a Substrate of FAT10ylation","volume":"125","author":"Aichem A.","year":"2012","journal-title":"Journal of Cell Science"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2022.2076770"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1508-21.2022"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.09.004"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/15230864251395963"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1797280"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00585-z"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.101.005"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.56"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702824200"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004987"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12905"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC02937C"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.07.039"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.07.009"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201846238"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.40"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.030"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02746-z"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E24-03-0101"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4840"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.07.021"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201009067"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.01.004"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202512725"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-023-00500-6"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.216671"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2361574"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2468907"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92408-4"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.09.024"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2025062"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.09.026"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-00978-9"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6663"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.09.009"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu9555"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534666231208633"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00052.2025"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.07.012"},{"key":"e_1_2_12_73_1","first-page":"1","article-title":"TRIM21\u2010mediated Ubiquitination of SQSTM1\/p62 Abolishes Its Ser403 Phosphorylation and Enhances Palmitic Acid Cytotoxicity","volume":"21","author":"Yang P.","year":"2024","journal-title":"Autophagy"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav4570"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170699"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26295"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.045"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107206"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002643"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0017-2"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797858"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2256135"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf064"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157047"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.078"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108659"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.295"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.11.061"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121898"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11090906"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-025-01542-3"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02742-14"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12030"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00620-10"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1159\/000373989"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0310037"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00712.2024"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110427"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03666-z"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13171431"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13252"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2020.1732955"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115016"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05061-8"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2481661"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02349-z"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62558-4"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02154-5"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1686729"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2020.103539"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032847"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1644076"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55446-w"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1147667"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-015-0230-9"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52534-6"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163029"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-50"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade0764"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.443"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2025.2547975"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414550"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.055"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100695"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29742"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-026-01672-9"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2024.06.001"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2026098"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07605-0"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53100-z"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00308-25"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102217"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109102"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2025046"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02891-2"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbaf119"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP286460"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300349R"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106043"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04507-8"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01851-y"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116822"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellin.2024.100186"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1293-3"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002954"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01493-w"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03404-7"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.780874"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.005"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01437-24"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2025.111066"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2025.110374"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virs.2024.01.005"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202104129"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI168544"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16091440"},{"key":"e_1_2_12_157_1","first-page":"1","article-title":"Serine Ubiquitination of SQSTM1 Regulates NFE2L2\u2010dependent Redox Homeostasis","volume":"21","author":"Mukherjee R.","year":"2024","journal-title":"Autophagy"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13151256"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.280065"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1661"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2024.12619"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.10.083"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154668"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.04.030"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143626"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174628"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2023.27.5.449"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00513"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-023-02213-w"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12091695"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26020439"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02705-z"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1092475"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2025.117528"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409740"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291905"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.70005"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196371"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.207068"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00091"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800425"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2521555123"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463352"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2534"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.11.028"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47569-x"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1024-4_15"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.3c00144"},{"issue":"203","key":"e_1_2_12_189_1","article-title":"Histone Modification Screening Using Liquid Chromatography, Trapped Ion Mobility Spectrometry, and Time\u2010Of\u2010Flight Mass Spectrometry","author":"Fernandez\u2010Rojas M.","year":"2024","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c14454"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2024.118050"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44320-024-00050-9"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.12.003"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.12.004"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0352-2"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0345-1"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-66508-y"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01462-8"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35886-6"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.72826"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0557-5"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c02150"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-025-02793-8"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51889-3"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-025-00915-1"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:58:38Z","timestamp":1792040318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":204,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mco2.70949"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70949","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"e70949"}}