{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:09:02Z","timestamp":1790060942804,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402634"],"award-info":[{"award-number":["82402634"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2508085Y055"],"award-info":[{"award-number":["2508085Y055"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Excessive inflammatory responses are a primary driver of acute lung injury, yet the underlying molecular mechanisms remain incompletely understood. In this study, we identify SKP2, an E3 ubiquitin ligase, as a critical negative regulator of pulmonary inflammation during methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) infection. Mechanistically, SKP2 promotes the degradation of its direct substrate p27\n                    <jats:sup>kip1<\/jats:sup>\n                    (p27), which functions as an activator of a noncanonical NF\u2010\u03baB signaling pathway. We further demonstrate that p27 facilitates the recruitment of p38 kinase to heterogeneous nuclear ribonucleoprotein\u2010U (hnRNPU), leading to direct phosphorylation of the transcriptional repressor FOXN3 at serine residues 83 and 85. This dual phosphorylation event triggers subsequent proteasomal degradation of FOXN3, thereby relieving transcriptional repression and enabling NF\u2010\u03baB\u2013driven activation of pro\u2010inflammatory genes. In vivo, genetic ablation of\n                    <jats:italic>Skp2<\/jats:italic>\n                    worsens pulmonary inflammatory injury, elevates neutrophil infiltration, and significantly reduces survival in MRSA\u2010infected mice, and these effects are greatly rescued by concurrent p27 depletion. Collectively, our findings uncover the SKP2\u2013p27\u2013FOXN3 axis as a pivotal regulatory module in pulmonary inflammation and suggest that targeting this axis may offer a promising therapeutic strategy for bacterial infection\u2010induced lung injury.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70963","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:50:11Z","timestamp":1789195811000},"source":"Crossref","is-referenced-by-count":0,"title":["SKP2 Regulates Pulmonary Inflammatory Injury Triggered by Bacterial Infection Through p27\u2010Mediated Degradation of FOXN3"],"prefix":"10.1002","volume":"7","author":[{"given":"Jinjin","family":"Yu","sequence":"first","affiliation":[{"name":"Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University  Bengbu China"},{"name":"Regenerative Medicine Sciences Cluster, Advanced Medical and Dental Institute Universiti Sains Malaysia  Kepala Batas Malaysia"},{"name":"Molecular Diagnosis Center First Affiliated Hospital Bengbu Medical University  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghong","family":"Hu","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Respiratory and Critical Care Medicine First Affiliated Hospital Bengbu Medical University  Bengbu 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