{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:09:02Z","timestamp":1790060942073,"version":"4.0.1"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0550604"],"award-info":[{"award-number":["2025ZD0550604"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2024YCJH\u2010KYXM0098"],"award-info":[{"award-number":["CSTB2024YCJH\u2010KYXM0098"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013160","name":"Venture and Innovation Support Program for Chongqing Overseas Returnees","doi-asserted-by":"publisher","award":["203011220240002"],"award-info":[{"award-number":["203011220240002"]}],"id":[{"id":"10.13039\/501100013160","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["GWIV\u201027.7"],"award-info":[{"award-number":["GWIV\u201027.7"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cardiovascular diseases (CVD) remain a leading cause of death globally, yet assessing the combined impact of multiple metabolic disorders on CVD risk is challenging due to a lack of comprehensive tools. We aimed to develop and validate a novel CVD screening model based on metabolic clustering networks. Using data from 4066 adults enrolled in the STONE study (China) through stratified sampling, we constructed a holistic network map of metabolic health, incorporating obesity, dyslipidemia, glucose disorders, and hepatic, renal, thyroid, and bone conditions. Through network analysis, 12 central and clinically accessible indicators\u2014including abdominal obesity, fatty liver, LDL\u2010C, HbA\n                    <jats:sub>1c<\/jats:sub>\n                    , eGFR, TSH, and bone density\u2014were selected to establish the CardioMet12 scoring system, with an AUC of 0.771 (95% CI: 0.733\u20130.808), sensitivity of 0.756, and specificity of 0.732. A score above 56 corresponded to an observed CVD prevalence exceeding 50% in the STONE cohort. External validation in an independent US population\u2010based epidemiological sample demonstrated satisfactory performance. Higher scores were significantly associated with metabolic syndrome diagnosis and advanced cardiovascular\u2010kidney\u2010metabolic staging in both cohorts. In conclusion, CardioMet12 is a robust metric that captures the complex interplay among multiple metabolic disorders, offering a comprehensive and proactive tool for enhanced CVD screening and risk evaluation.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70967","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:59:06Z","timestamp":1788505146000},"source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Metabolic\u2010Cardiovascular Disease Nexus: An Epidemiological Network Analysis Identifies Central Indicators"],"prefix":"10.1002","volume":"7","author":[{"given":"Xin\u2010yi","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology No. 905 Hospital of PLA Navy Shanghai Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan\u2010cai","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Changhai Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Statistics School of Public Health Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010quan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Changzheng Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10762"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab309"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00059.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61794-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001186"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0302.102575"},{"issue":"2","key":"e_1_2_12_11_1","first-page":"172","article-title":"Adding Social Deprivation and family History to Cardiovascular Risk Assessment: The ASSIGN Score From the Scottish Heart Health Extended Cohort (SHHEC)","volume":"93","author":"Woodward M.","year":"2007","journal-title":"Heart (British Cardiac Society)"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001741"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-15183-6"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1676833"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46122"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.739714"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67663-5"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405182"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01039-5"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.007"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01125-5"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001078"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.1873"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-6-200409210-00007"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027569.76671.A8"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.761520"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.12.022"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.60"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.09.022"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65252"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.4514"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2409275"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325669"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60674-5"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.531"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00040-6"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.64"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050711"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-018-1039-z"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16546"},{"key":"e_1_2_12_43_1","first-page":"187","article-title":"On some Extensions to GA Package: Hybrid Optimisation, Parallelisation and Islands EvolutionOn some Extensions to GA Package: Hybrid Optimisation, Parallelisation and Islands Evolution","volume":"9","author":"Scrucca L.","year":"2017","journal-title":"R Journal"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v053.i04"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.6892"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001184"},{"key":"e_1_2_12_47_1","unstructured":"D. C.GoffJr. D. M.Lloyd\u2010Jones G.Bennett et\u00a0al. \u201c2013 ACC\/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines \u201dCirculation129 no. 25 Suppl 2 (2014):S49\u2013S73."},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.32164"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.814251"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.6.611"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq448"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab075"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101943"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.351"},{"key":"e_1_2_12_56_1","first-page":"37","article-title":"Metabolic Biomarkers for Predicting Cardiovascular Disease","volume":"9","author":"Montgomery J. E.","year":"2013","journal-title":"Vascular Health and Risk Management"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70878"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-20-263"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-6-33"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01840-4"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533257"},{"issue":"5","key":"e_1_2_12_62_1","first-page":"609","article-title":"Expert Consensus on Obesity Prevention and Treatment in China","volume":"43","year":"2022","journal-title":"Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.26599\/1671-5411.2023.09.008"},{"key":"e_1_2_12_64_1","unstructured":"National Association of Community Health Centers \u201cProtocol for Responding to and Assessing Patients' Assets Risks and Experiences (PRAPARE) Implementation and Action ToolkitProtocol for Responding to and Assessing Patients' Assets Risks and Experiences (PRAPARE) Implementation and Action Toolkit \u201dNational Association of Community Health Centers 2024."},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1135"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097034"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00519-5"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.2196\/21798"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70967","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:49:39Z","timestamp":1790059779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":67,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mco2.70967"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70967","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"e70967"}}