{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:09:07Z","timestamp":1790060947240,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572883"],"award-info":[{"award-number":["82572883"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772347"],"award-info":[{"award-number":["2025M772347"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Full\u2010thickness wounds remain a major clinical challenge, and tissue\u2010engineered skin using epidermal stem cells (EpiSCs) offers a promising strategy for bio\u2010inspired reconstruction. In this randomized controlled trial, 232 patients with full\u2010thickness defects (\u2265 9 cm\n                    <jats:sup>2<\/jats:sup>\n                    ) received either standard treatment (acellular dermal matrix [ADM] + split\u2010thickness skin graft [STSG],\n                    <jats:italic>n<\/jats:italic>\n                    = 112) or cell therapy (ADM + STSG + EpiSC suspension,\n                    <jats:italic>n<\/jats:italic>\n                    = 120). Autologous EpiSCs were prepared intraoperatively in a single step, avoiding prolonged in vitro expansion. The primary outcome was 6\u2010month scar quality assessed by the Vancouver Scar Scale (VSS), while secondary outcomes included 2\u2010week healing and 3\u2010month recurrence. Compared with standard treatment, cell therapy produced significantly lower total VSS scores (median 3.0\u00a0vs. 6.0,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and improved complete wound healing at 2 weeks (80\/120 [66.7%] vs. 61\/112 [54.5%]; adjusted odds ratios [OR] = 1.87, 95% confidence interval [CI] 1.06\u20133.28,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.029). Complete healing at 2 weeks was associated with reduced 3\u2010month recurrence (adjusted OR = 0.26, 95% CI 0.09\u20130.75,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.012). These findings support intraoperative EpiSC\u2010enhanced composite grafting as an effective and clinically translatable approach for rapid closure and improved long\u2010term scar outcomes.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70973","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:18:13Z","timestamp":1788747493000},"source":"Crossref","is-referenced-by-count":0,"title":["Bio\u2010Inspired Skin Reconstruction Using Intraoperative Autologous Epidermal Stem Cell\u2013Enhanced Composite Grafts: A Randomized Trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Zhicheng","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Department of Burns and Plastic Surgery Linfen Central Hospital Linfen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dermatology Hospital of Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery The Third Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery Sixth Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery Huizhou Central People's Hospital  Huizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery The First People's Hospital of Zhaoqing  Zhaoqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery &amp; Burn Surgery Shenzhen Hospital Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Department of Wound Repair Surgery Affiliated Hospital of Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2020.0339"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2023.0150"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.07.028"},{"key":"e_1_2_11_5_1","first-page":"58","volume-title":"Biomaterials for Treating Skin Loss","author":"Imahara S. 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