{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:46:12Z","timestamp":1792043172323,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92478101"],"award-info":[{"award-number":["92478101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172731"],"award-info":[{"award-number":["82172731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune diseases for which robust molecular classifiers are lacking. In this retrospective cross\u2010sectional study, we profiled immunoglobulin G (IgG) subclass\u2010specific\n                    <jats:italic>N<\/jats:italic>\n                    \u2010glycosylation in IIMs and investigated their associations with clinical phenotypes and histopathological features. Using liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS) with an electron\u2010transfer\/higher energy collisional dissociation\u2010stepped collision energy higher energy collisional dissociation (EThcD\u2010sceHCD) fragmentation strategy, we analyzed plasma samples from 145 patients with IIMs and 52 age\u2010 and sex\u2010comparable healthy controls (HCs). Compared with HCs, patients with IIMs showed increased core fucosylation and significant alterations in 13 site\u2010specific IgG glycopeptides. Unsupervised clustering identified three glycosylation\u2010defined endotypes with muscle\u2010, cutaneous\u2010, and joint\u2010dominant phenotypes, each characterized by distinct glycoform patterns, clinical manifestations, and serological profiles. Specific IgG2 glycoforms were associated with markers of muscle injury and membrane attack complex (C5b\u20109) deposition, suggesting a link between IgG glycosylation and complement\u2010mediated tissue damage. A seven\u2010glycopeptide multinomial logistic regression model and endotype\u2010specific nomograms were developed for exploratory cluster assignment, with moderate discrimination in the internal validation cohort (macro\u2010averaged area under the curve [macro\u2010AUC], 0.74). These findings identify IgG subclass\u2010specific\n                    <jats:italic>N<\/jats:italic>\n                    \u2010glycosylation as a molecular layer underlying IIM heterogeneity beyond conventional clinical classification and provide a glycoproteomic framework for biomarker\u2010driven stratification, histopathological interpretation, and future mechanistic investigation.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70987","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:00:33Z","timestamp":1790100033000},"source":"Crossref","is-referenced-by-count":0,"title":["Glycoproteomic Signatures of IgG Subclass\n                    <i>N<\/i>\n                    \u2010Glycosylation Reveal Molecular Endotypes in Idiopathic Inflammatory Myopathies"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7188-2352","authenticated-orcid":false,"given":"Tong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Laboratory of Rheumatology and Immunology West China Hospital Sichuan University  Chengdu China"},{"name":"Institute of Immunology and Inflammation Frontiers Science Center For Disease\u2010related Molecular Network West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Laboratory of Rheumatology and Immunology West China Hospital Sichuan University  Chengdu China"},{"name":"Institute of Immunology and Inflammation Frontiers Science Center For Disease\u2010related Molecular Network West China Hospital Sichuan University  Chengdu 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