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Twenty patients received the combination every 3 weeks for six cycles before surgery. In the intention\u2010to\u2010treat population, the pathologic complete response (pCR) was 20.0% (four out of 20; 95% CI, 5.7\u201343.7%), and the objective response rate (ORR) was 45.0% (nine out of 20; 95% CI, 23.1\u201368.5%). Among 16 patients who completed protocol\u2010defined treatment and surgery, pCR was 25.0% (four out of 16; 95% CI, 7.3\u201352.4%), ORR was 56.3% (nine out of 16; 95% CI, 29.9\u201380.2%), and 31.3% achieved residual cancer burden Class 0\u20131. Grade \u22653 adverse events occurred in 25.0%; no treatment\u2010related deaths occurred. pCR\u2010associated tumors had a pretreatment immune\u2010active microenvironment enriched in inflammatory proteins, transcripts, and tumor\u2010infiltrating lymphocytes, whereas nonresponders displayed a higher M2\/M1 macrophage ratio. An exploratory baseline score combining CCL19 and the M2\/M1 ratio showed pCR\/non\u2010pCR separation (AUC\u00a0=\u00a00.8889) but attenuated on internal validation (LOOCV AUC\u00a0=\u00a00.6667, optimism\u2010corrected bootstrap AUC\u00a0=\u00a00.8375). This combination showed preliminary antitumor activity with manageable safety; however, given the small sample size and wide confidence intervals, these findings preclude definitive conclusions about efficacy and warrant validation in larger randomized controlled trials.<\/jats:p>","DOI":"10.1002\/mco2.70988","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:02:27Z","timestamp":1791100947000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2\u2010Low Breast Cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Xiaoxiao","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Breast Health Medicine Sichuan Provincial Engineering Research Center of Intelligent Diagnosis and Treatment of Breast Diseases Breast Center Department of Medical Oncology Cancer Center West China Hospital Sichuan University  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