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In an open\u2010label, single\u2010arm Phase Ib trial at two tertiary hospitals, we evaluated parsaclisib plus chidamide with step\u2010down maintenance. Adults with R\/R PTCL received parsaclisib 10\u201320\u00a0mg once daily plus chidamide 20\u00a0mg twice weekly for 8 weeks using 3+3 escalation; patients without progression or unacceptable toxicity continued parsaclisib 2.5\u00a0mg once daily plus chidamide 20\u00a0mg twice weekly. Primary endpoints were Cycle 1 dose\u2010limiting toxicities (DLTs), treatment\u2010related adverse events, and recommended Phase II dose; antitumor activity and biomarker correlates were exploratory. Twelve screened patients were enrolled and treated. One Grade 3 hepatotoxicity DLT occurred; no maximum tolerated dose was reached; parsaclisib 20\u00a0mg once daily plus chidamide 20\u00a0mg twice weekly was selected for Phase II. No Grade 4 treatment\u2010related events or treatment\u2010related deaths occurred. Objective and complete response rates were 58% (95% CI, 28\u201385) and 42% (95% CI, 15\u201372). With 26.8 months\u2019 median follow\u2010up, 2\u2010year progression\u2010free and overall survival rates were 33.3 and 66.7%. Exploratory analyses suggested TET2 alterations and natural killer\u2010cell expansion as correlates of durable remission. This regimen warrants prospective validation (ClinicalTrials.gov: NCT05083208).<\/jats:p>","DOI":"10.1002\/mco2.70993","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:12:31Z","timestamp":1790925151000},"source":"Crossref","is-referenced-by-count":0,"title":["All\u2010Oral PI3K\u03b4 and HDAC Inhibition with Parsaclisib Plus Chidamide and Step\u2010Down Maintenance in Relapsed or Refractory Peripheral T\u2010Cell Lymphoma: A Phase Ib Trial"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-652X","authenticated-orcid":false,"given":"Xufeng","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchi","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuna","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lymphoma the People's Hospital of Jiaozuo City  Jiaozuo Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Lymphoma the People's Hospital of Jiaozuo City  Jiaozuo Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quande","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Si","sequence":"additional","affiliation":[{"name":"Clinical Medical College Henan University of Chinese Medicine  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Miao","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medicine Science Henan University of Chinese Medicine  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; 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