{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:02Z","timestamp":1792043102358,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Liver metastasis is a key driver of immune tolerance in melanoma, limiting immune checkpoint inhibitor efficacy. This prospective single\u2010arm phase II trial investigated the efficacy and safety of co\u2010ablation combined with sintilimab for liver\u2010metastatic melanoma (ChiCTR2200061591). Eligible patients received sintilimab (anti\u2010PD\u20101, 200 mg every 3 weeks) for up to eight cycles alongside co\u2010ablation. The primary endpoint was a 6\u2010month progression\u2010free survival (PFS) rate per Response Evaluation Criteria in Solid Tumors v1.1. Secondary endpoints included overall survival (OS), PFS time, and overall response rate (ORR). Between June 2022 and July 2025, 16 patients were enrolled. Three patients achieved a partial response (ORR 18.75%). The 6\u2010month PFS rate was 31.25% (95% confidence interval [CI]: 15.1\u201364.6), with a median PFS of 3.94 months (95% CI: 2.77\u201314.30). The 12\u2010 and 24\u2010month OS rates were 53.8% (95% CI: 33.7\u201386.0) and 28.7% (10.3\u201380.1), respectively; median OS was 16.67 months (95% CI: 7.50\u2013NR). Grade \u2265 3 treatment\u2010related adverse events occurred in 14 of 16 patients (87.5%), the most common being elevated liver enzyme levels. Co\u2010ablation combined with sintilimab demonstrates a manageable safety profile and encouraging antitumor activity in patients with liver\u2010metastatic melanoma, meriting further evaluation.<\/jats:p>","DOI":"10.1002\/mco2.70997","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:13:48Z","timestamp":1789460028000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Co\u2010Ablation Combined With Aintilimab for Metastatic Melanoma to the Liver (CryoCheck\u2010001): A Phase II Trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Lujun","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Minimally Invasive Interventional Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Sun Yat\u2010sen University  Guangzhou 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