{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:44:55Z","timestamp":1792043095498,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571240"],"award-info":[{"award-number":["82571240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271105"],"award-info":[{"award-number":["82271105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301230"],"award-info":[{"award-number":["82301230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["Y03023206300324029"],"award-info":[{"award-number":["Y03023206300324029"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dry age\u2010related macular degeneration (AMD), affecting over 196 million people globally, represents the leading cause of irreversible blindness with limited disease\u2010modifying therapies. The disease is characterized by progressive retinal pigment epithelium (RPE) degeneration driven by ferroptosis, an iron\u2010dependent form of regulated cell death. While mesenchymal stem cell (MSC)\u2010derived extracellular vesicles (EVs) show therapeutic promise, their mechanisms in counteracting RPE ferroptosis remain unexplored. Here, we prove that human umbilical cord MSC\u2010derived EVs (hucMSC\u2010EVs) significantly attenuate NaIO\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced retinal degeneration, preserving retinal structure and improving visual function in mice. Transcriptomic profiling identified Lipocalin\u20102 (\n                    <jats:italic>Lcn2<\/jats:italic>\n                    ) as a key ferroptosis\u2010related target. MSC\u2010EVs administration markedly downregulated Lcn2 and upregulated Gpx4 in NaIO\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced models, demonstrating potent ferroptosis suppression. Furthermore, AAV\u2010mediated\n                    <jats:italic>Lcn2<\/jats:italic>\n                    overexpression induced AMD\u2010like retinal pathology, which was effectively attenuated by subsequent MSC\u2010EVs treatment. Small RNA sequencing reveals miR\u2010486\u20103p as the key factor in the MSC\u2010EVs, and dual\u2010luciferase reporter assays confirm its direct binding to the\n                    <jats:italic>Lcn2<\/jats:italic>\n                    3'UTR. Functional validation demonstrates that miR\u2010486\u20103p agomir recapitulates the effects of MSC\u2010EVs, including preservation of retinal structure and improvement of electrophysiological responses. Our findings establish a novel strategy where hucMSC\u2010EVs deliver miR\u2010486\u20103p to suppress Lcn2\u2010mediated ferroptosis, offering a potential treatment for dry AMD.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71000","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:48:51Z","timestamp":1789627731000},"source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal Stem Cell\u2010Derived Extracellular Vesicles Ameliorate NaIO\n                    <sub>3<\/sub>\n                    \u2010Induced Dry AMD by Delivering miR\u2010486\u20103p to Inhibit Lipocalin\u20102\u2010Mediated Ferroptosis"],"prefix":"10.1002","volume":"7","author":[{"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tujing","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ye","sequence":"additional","affiliation":[{"name":"The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Li","sequence":"additional","affiliation":[{"name":"The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaping","family":"Tian","sequence":"additional","affiliation":[{"name":"The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Liao","sequence":"additional","affiliation":[{"name":"The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulin","family":"Huang","sequence":"additional","affiliation":[{"name":"The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China"},{"name":"Chongqing Key Laboratory of Innovative Chinese Medicine and Health Intervention Chongqing Academy of Chinese Materia Medica Chongqing University of Chinese Medicine Chongqing 402760 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2021.02.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26074"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252313053"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000657"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2024.101323"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1810918"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05121-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101971"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04924-4"},{"issue":"2","key":"e_1_2_10_12_1","first-page":"273","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism","volume":"171","author":"Stockwell B. 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