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Here, we identify adipocyte\u2010derived kinesin family member 13B (KIF13B) as a regulator of obesity\u2010associated metabolic dysfunction through lipoprotein receptor\u2010related protein 1 (LRP1)\/peroxisome proliferator\u2010activated receptor \u03b3 (PPAR\u03b3) signaling. KIF13B expression is markedly upregulated in adipose tissue from humans and mice with obesity. Adipocyte\u2010specific\n                    <jats:italic>Kif13b<\/jats:italic>\n                    deletion protected mice from high\u2010fat diet\u2010induced weight gain, adipose expansion and inflammation, dyslipidemia, insulin resistance, and hepatic steatosis, while promoting thermogenic remodeling. In mice with established diet\u2010induced obesity, adeno\u2010associated virus serotype 9 (AAV9)\u2010mediated adipocyte\u2010targeted KIF13B knockdown improved adipose inflammation, lipid and glucose homeostasis, and liver injury; selected metabolic benefits were also observed in\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice. Mechanistically, KIF13B facilitates PPAR\u03b3\u2010responsive transcriptional activity and adipogenic lipid accumulation via LRP1. This proadipogenic KIF13B\/LRP1\/PPAR\u03b3 axis is further supported by human adipose transcriptomic analyses, which reveal positive correlations among its components in obesity and Type 2 diabetes. These findings define a previously unrecognized KIF13B\u2013LRP1\u2013PPAR\u03b3 axis linking intracellular trafficking to pathological adipocyte remodeling and support adipocyte KIF13B as a potential therapeutic target for obesity\u2010associated metabolic disease.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71003","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:52:02Z","timestamp":1789627922000},"source":"Crossref","is-referenced-by-count":0,"title":["Adipocyte\u2010Derived KIF13B Aggravates Obesity\u2010Associated Metabolic Dysfunction via LRP1\/PPAR\u03b3 Signaling"],"prefix":"10.1002","volume":"7","author":[{"given":"Guolin","family":"Miao","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"},{"name":"Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden","family":"Xian","sequence":"additional","affiliation":[{"name":"Shepton High School  Plano Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion Peking University Third Hospital  Beijing 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