{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:04Z","timestamp":1792043104607,"version":"4.4.0"},"reference-count":253,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancer remains a critical global health concern due to late detection, drug resistance, and high mortality. Mesothelin (MSLN) is a glycoprotein highly expressed on the surface of various cancer cells, including those of ovarian, pancreatic, and gastric cancers. Thus, it could be a valuable target for both as a biomarker and for immunotherapy. This review summarizes MSLN biology in cancer, current immunotherapeutic strategies targeting MSLN, associated clinical challenges, and emerging avenues to enhance immunotherapy efficacy. During cancer progression, MSLN acts as a cellular accelerator, promoting cell division and survival. It activates several critical signaling pathways, including nuclear factor k\u2010light\u2010chain\u2010enhancer of activated B cells\u00a0(NF\u2010\u03baB), interleukin\u20106 and its soluble receptor\u00a0(IL\u20106\/sIL\u20106R), and c\u2010Jun N\u2010terminal kinase (JNK), thereby promoting epithelial\u2013mesenchymal transition and angiogenesis. Various MSLN\u2010targeting immunotherapies, including monoclonal antibodies, chimeric antigen receptor\u2010T cells, cytokine therapies, and vaccines, have shown preclinical and early clinical efficacy. However, immune evasion, an immunosuppressive tumor microenvironment, antigen heterogeneity, tumor immune escape, and off\u2010tumor toxicities continue to hinder the broad clinical success of these modalities. Nonetheless, rational combinations of MSLN\u2010directed therapies with other immunomodulatory strategies, optimized patient stratification, and advances in vaccine and adoptive cell therapy design hold promise for overcoming resistance and improving patient outcomes.<\/jats:p>","DOI":"10.1002\/mco2.71009","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:25:06Z","timestamp":1790321106000},"source":"Crossref","is-referenced-by-count":0,"title":["Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-9471","authenticated-orcid":false,"given":"Manoj Kumar","family":"Gupta","sequence":"first","affiliation":[{"name":"Hematology, Hemostasis, Oncology, and Stem Cell Transplantation Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishna","family":"Vadde","sequence":"additional","affiliation":[{"name":"Department of Biotechnology &amp; Bioinformatics Yogi Vemana University  Kadapa Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganji Purnachandra","family":"Nagaraju","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology Heersink School of Medicine The University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70043"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-026-04219-7"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21858"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05467-z"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02218-1"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0134-x"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-022-03290-6"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2025.2603105"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1309\/F1B64CL7H8VJKEAF"},{"key":"e_1_2_15_11_1","first-page":"3862","article-title":"Mesothelin is 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