{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:30Z","timestamp":1792043130213,"version":"4.4.0"},"reference-count":203,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571202"],"award-info":[{"award-number":["81571202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82602674"],"award-info":[{"award-number":["82602674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202506380239"],"award-info":[{"award-number":["202506380239"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Peripheral nerve injury (PNI) affects 13\u201323 individuals per 100,000 annually, and functional recovery hinges on faithful remyelination of regenerating axons by Schwann cells (SCs). This review integrates the complete molecular logic governing the transition from injury\u2010induced SC plasticity to mature myelin regeneration. The hierarchical transcriptional program\u2014from SOX10 pioneer factor engagement through OCT6\u2010mediated promyelinating transition to KROX20\/EGR2\u2010driven activation of compact myelin genes\u2014and the instructive role of axonal Neuregulin\u20101 Type III signaling are dissected. Wallerian degeneration via the NMNAT2\u2013SARM1\u2010mediated axon degeneration cascade, c\u2010JUN\u2010dependent SC reprogramming, and the epigenetic and noncoding RNA mechanisms that re\u2010engage myelination are examined. The immune microenvironment is considered as a temporally layered network in which macrophage polarization, macrophage\u2010to\u2010myofibroblast transition, and regulatory T cell activity coordinate the transition from inflammation to repair. Finally, this review critically evaluates emerging therapeutic strategies\u2014including Neuregulin\u20101 supplementation, SC transplantation, nerve guidance conduits, electrical stimulation, and senolytic clearance of aged SCs\u2014and argues that rationally sequenced combination therapies will be required to achieve transformative improvements in functional recovery after severe PNI. This review provides a mechanistic roadmap for designing next\u2010generation regenerative strategies aimed at restoring saltatory conduction.<\/jats:p>","DOI":"10.1002\/mco2.71019","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:20:26Z","timestamp":1791782426000},"source":"Crossref","is-referenced-by-count":0,"title":["Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9146-4278","authenticated-orcid":false,"given":"Li\u2010Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Bo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Yi","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Mou","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Tian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6652-1415","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(49)92367-3"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400357"},{"key":"e_1_2_17_4_1","first-page":"100","article-title":"Neurobiology of Peripheral Nerve Injury, Regeneration, and Functional Recovery: From Bench Top Research to Bedside Application","volume":"13","author":"Sulaiman W.","year":"2013","journal-title":"Ochsner Journal"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40919"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.186601"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20767"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200912142"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22310"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.258203"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.14.1751"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/371796a0"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00282-3"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.021"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0986-17.2017"},{"key":"e_1_2_17_16_1","first-page":"E8072","article-title":"Schwann Cells Use TAM Receptor\u2010Mediated Phagocytosis in Addition to Autophagy to Clear Myelin in a Mouse Model of Nerve Injury","volume":"114","author":"Lutz A. B.","year":"2017","journal-title":"PNAS"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01083-w"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00069"},{"key":"e_1_2_17_19_1","first-page":"209","article-title":"Node of Ranvier Disruption as a Cause of Neurological Diseases","volume":"5","author":"Susuki K.","year":"2013","journal-title":"American Society for Neurochemistry Neuro"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199809)24:1<8::AID-GLIA2>3.0.CO;2-3"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.03.068"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081832"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae158"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040812"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0686-09.2009"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80176-2"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh048"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8370-x"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199609000-00001"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R009761"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1426"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200110003"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00680-7"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2021-108105"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2013-0146"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks313"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400573"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06498.x"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060810"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.70053"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.1.155"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21173"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24610"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-03090-0"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2895-11.2012"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.15.6873"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1490"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803330200"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0716-06.2006"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.065490"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0326-08.2008"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12112594"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.06.006"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407836102"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00318"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01689-06"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20761"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/23262133.2016.1271495"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.150656"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2686"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095862"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.017"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4321"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2323"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1746"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2257-14.2015"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1370-16.2016"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23500"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4316"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23949"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15161"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20982"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.310490.117"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115400"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0659-11.2011"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200803013"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws353"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2762"},{"key":"e_1_2_17_79_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2020.0384","article-title":"Augustus Volney Waller: Physiologist Who Described Distal Degeneration of Severed Nerve Fibres","volume":"81","author":"Ellis H.","year":"2020","journal-title":"Br J Hosp Med (Lond)"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3680"},{"key":"e_1_2_17_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000300"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2020.02.012"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.297070"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0269-3"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1482-4"},{"key":"e_1_2_17_86_1","article-title":"Nerve Injury\u2010Induced c\u2010Jun Activation in Schwann Cells Is JNK Independent","volume":"2014","author":"Blom C. L.","year":"2014","journal-title":"BioMed research international"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1453-17.2017"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201205025"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0416"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2009.26.2.E3"},{"key":"e_1_2_17_91_1","first-page":"390","article-title":"Nerve Conduit Filled With GDNF Gene\u2010Modified Schwann Cells Enhances Regeneration of the Peripheral Nerve","volume":"32","author":"Wang X.","year":"2012","journal-title":"Microsurgery"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62232"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(200012)32:3<234::AID-GLIA40>3.0.CO;2-3"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23532"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3619-17.2018"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2308157"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4814-11.2012"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00033"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201503019"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270874"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20766"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10108"},{"key":"e_1_2_17_103_1","first-page":"54","article-title":"Modulating Schwann Cell Behavior via Functional Nerve Guidance Conduits for Enhanced Peripheral Nerve Regeneration","volume":"10","author":"Yang K.","year":"2025","journal-title":"Nature Partner Journal Regenerative Medicine"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09385-6"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3521-15.2016"},{"key":"e_1_2_17_106_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29241"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-02916-2"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100852"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02273-1"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073440"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201611150"},{"key":"e_1_2_17_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0801-10.2010"},{"key":"e_1_2_17_113_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012450"},{"key":"e_1_2_17_114_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202501968R"},{"key":"e_1_2_17_115_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858410373835"},{"key":"e_1_2_17_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2015.02.010"},{"key":"e_1_2_17_117_1","first-page":"1","article-title":"Survival of Adult Neurons Lacking Cholesterol Synthesis in Vivo","volume":"8","author":"F\u00fcnfschilling U.","year":"2007","journal-title":"BMC Neuroscience [Electronic Resource]"},{"key":"e_1_2_17_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905633106"},{"key":"e_1_2_17_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwab046"},{"key":"e_1_2_17_120_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20130046"},{"key":"e_1_2_17_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02497-9"},{"key":"e_1_2_17_122_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2024.0100"},{"key":"e_1_2_17_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-026-01536-9"},{"key":"e_1_2_17_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.08.050"},{"key":"e_1_2_17_125_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.253510"},{"key":"e_1_2_17_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.021"},{"key":"e_1_2_17_127_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05731.1999"},{"key":"e_1_2_17_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115194"},{"key":"e_1_2_17_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1594435"},{"key":"e_1_2_17_130_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02602.2000"},{"key":"e_1_2_17_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.09.020"},{"key":"e_1_2_17_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22558"},{"key":"e_1_2_17_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-019-03511-0"},{"key":"e_1_2_17_134_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231244"},{"key":"e_1_2_17_135_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001879"},{"key":"e_1_2_17_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15916"},{"key":"e_1_2_17_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.021"},{"key":"e_1_2_17_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.054"},{"key":"e_1_2_17_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45742-w"},{"key":"e_1_2_17_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.923152"},{"key":"e_1_2_17_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402391101"},{"key":"e_1_2_17_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"e_1_2_17_143_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202317907"},{"key":"e_1_2_17_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.06.016"},{"key":"e_1_2_17_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1603752"},{"key":"e_1_2_17_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12344"},{"key":"e_1_2_17_147_1","first-page":"554","article-title":"Senolytics in Idiopathic Pulmonary Fibrosis: Results From a First\u2010in\u2010Human, Open\u2010Label, Pilot Study","volume":"40","author":"Justice J. N.","year":"2019","journal-title":"Electronic Biomedicine"},{"key":"e_1_2_17_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1228282"},{"key":"e_1_2_17_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12898"},{"key":"e_1_2_17_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156033"},{"key":"e_1_2_17_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910785"},{"key":"e_1_2_17_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12387"},{"key":"e_1_2_17_153_1","article-title":"Current Understanding of the Molecular Mechanisms of Chemotherapy\u2010Induced Peripheral Neuropathy","volume":"17","author":"Chen X.","year":"2024","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_17_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.11.032"},{"key":"e_1_2_17_155_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181040"},{"key":"e_1_2_17_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2021.11.001"},{"key":"e_1_2_17_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.02.009"},{"key":"e_1_2_17_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10692"},{"key":"e_1_2_17_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3281"},{"key":"e_1_2_17_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.7"},{"key":"e_1_2_17_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00568"},{"key":"e_1_2_17_162_1","first-page":"160","article-title":"AAV9\u2010Mediated Schwann Cell\u2010Targeted Gene Therapy Rescues a Model of Demyelinating Neuropathy","volume":"29","author":"Sargiannidou I.","year":"2022","journal-title":"Gene Therapy"},{"key":"e_1_2_17_163_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7590"},{"key":"e_1_2_17_164_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg6241"},{"key":"e_1_2_17_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2249"},{"key":"e_1_2_17_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3887"},{"key":"e_1_2_17_167_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00246D"},{"key":"e_1_2_17_168_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0732"},{"key":"e_1_2_17_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1023"},{"key":"e_1_2_17_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.04.002"},{"key":"e_1_2_17_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2026.01.003"},{"key":"e_1_2_17_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12974"},{"key":"e_1_2_17_173_1","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.11.45"},{"key":"e_1_2_17_174_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.253516"},{"key":"e_1_2_17_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.001"},{"key":"e_1_2_17_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.12.030"},{"key":"e_1_2_17_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-018-0675-6"},{"key":"e_1_2_17_178_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12081128"},{"key":"e_1_2_17_179_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2022.0186"},{"key":"e_1_2_17_180_1","doi-asserted-by":"publisher","DOI":"10.31083\/JIN36965"},{"key":"e_1_2_17_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-015-0415-x"},{"key":"e_1_2_17_182_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.580654"},{"key":"e_1_2_17_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.78155"},{"key":"e_1_2_17_184_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-35552011005000008"},{"key":"e_1_2_17_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22426"},{"key":"e_1_2_17_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12121856"},{"key":"e_1_2_17_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-025-01652-z"},{"key":"e_1_2_17_188_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00038"},{"key":"e_1_2_17_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620761114"},{"key":"e_1_2_17_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-023-00019-5"},{"key":"e_1_2_17_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05420-0"},{"key":"e_1_2_17_192_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60467"},{"key":"e_1_2_17_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70025-4"},{"key":"e_1_2_17_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011952"},{"key":"e_1_2_17_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2024.138009"},{"key":"e_1_2_17_196_1","unstructured":"U. S.Food and Drug Administration \u201cFDA Approves Nerve Scaffold for the Treatment of Sensory Nerve Discontinuity \u201d December 3 2025."},{"key":"e_1_2_17_197_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42234-025-00171-y"},{"key":"e_1_2_17_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44386-025-00023-4"},{"key":"e_1_2_17_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44386-025-00016-3"},{"key":"e_1_2_17_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-025-02009-9"},{"key":"e_1_2_17_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202511019"},{"key":"e_1_2_17_202_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15877"},{"key":"e_1_2_17_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110108"},{"key":"e_1_2_17_204_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd9749"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.71019","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:55:29Z","timestamp":1792040129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.71019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":203,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mco2.71019"],"URL":"https:\/\/doi.org\/10.1002\/mco2.71019","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"e71019"}}