{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:46:13Z","timestamp":1792043173557,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271426"],"award-info":[{"award-number":["82271426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101461"],"award-info":[{"award-number":["82101461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sympathetic hyperactivity following acute brain injury (ABI) impedes recovery, yet effective treatments are lacking. Recently, N\n                    <jats:sup>6<\/jats:sup>\n                    \u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modified by fat mass and obesity\u2010associated gene (FTO) has been demonstrated to play critical roles in multiple neurological diseases. Here, we found that sympathetic hyperactivity occurred in traumatic brain injury and intracerebral hemorrhage patients and mouse models in vivo. In mouse ABI models, the RNA demethylase FTO was upregulated in hypothalamic neurons. Through m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation sequencing, we found that FTO mediated m\n                    <jats:sup>6<\/jats:sup>\n                    A demethylation of\n                    <jats:italic>Trhr<\/jats:italic>\n                    mRNA, enhancing its stability by inhibiting YTHDF2\u2010dependent decay. This increased neuronal TRHR expression and sensitivity to TRH, culminating in sympathetic hyperactivity. Conversely, restoring hypothalamic FTO or TRHR levels alleviated this condition. We further mapped and functionally validated a monosynaptic projection from lateral hypothalamic TRHR neurons to the rostral ventrolateral medulla (RVLM), demonstrating that modulating these neurons controls sympathetic tone. Collectively, our findings elucidate a novel FTO\u2013Trhr axis in post\u2010ABI autonomic dysfunction and highlight a promising therapeutic target.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71036","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:02:17Z","timestamp":1791183737000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by Regulating\n                    <i>Trhr<\/i>\n                    M\n                    <sup>6<\/sup>\n                    A Modification"],"prefix":"10.1002","volume":"7","author":[{"given":"Maoxing","family":"Fei","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Jinling Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"},{"name":"Department of Neurosurgery Northern Jiangsu People's Hospital Affiliated to Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Jinling Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"},{"name":"Department of Neurosurgery The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Affiliated Jinling Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department 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