{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:46:19Z","timestamp":1792043179894,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011930","name":"Beijing Medical and Health Foundation","doi-asserted-by":"publisher","award":["YWJKJJHKYJJ\u2010ABS\u20102025\u2010024"],"award-info":[{"award-number":["YWJKJJHKYJJ\u2010ABS\u20102025\u2010024"]}],"id":[{"id":"10.13039\/501100011930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473161"],"award-info":[{"award-number":["82473161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Clinically,\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation (\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mut) has long been simplistically dichotomized as mutant versus wildtype, overlooking their structural and functional complexity. The prognostic significance of\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2011mut in\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2011wildtype (\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2011wt) gliomas remains controversial. In 237\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2011wt gliomas, we integrated clinical, genomic, and follow\u2011up data to test whether mutation subtypes refine risk stratification. In this cohort, 73 patients (73\/237, 30.8%) harbored\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mut, which was significantly associated with worse overall survival. Subgroup analysis further revealed that patients with mutations in the \u03b2\u2011strand region had a median outcome of only 12.0 months, markedly inferior to those with mutations in the \u03b1\u2011helix (22.5 months), loop (23.9 months), and turn\/other regions (23.6 months). Multivariable Cox regression analysis showed that\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mut was an independent prognostic factor associated with worse outcome (HR\u00a0=\u00a01.91; 95%CI: 1.29\u20132.84;\n                    <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                    0.001). Notably,\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2011mut patients with variant allele frequency (VAF)\u226510% showed significantly worse survival than those with VAF&lt;10% (\n                    <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                    0.030), whereas VAF&lt;10% cases had survival comparable to\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2011wt. In addition, p53 immunohistochemistry score\u22654 yielded an area under the curve (AUC) of 0.79 for\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mut prediction. Collectively,\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mut in\n                    <jats:italic>IDH<\/jats:italic>\n                    \u2011wt gliomas are prognostically heterogeneous. A VAF\u2265\u00a010% identified a potential high\u2011risk subgroup, with \u03b2\u2010strand mutations associated with the poorest survival in our cohort. p53 immunohistochemistry offers a cost\u2011effective surrogate screen.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71041","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:58:35Z","timestamp":1791183515000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>TP53<\/i>\n                    Mutation Heterogeneity Refines Prognostic Stratification in\n                    <i>IDH<\/i>\n                    \u2010Wildtype Glioma"],"prefix":"10.1002","volume":"7","author":[{"given":"Kuilin","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Nanfang Hospital Southern Medical University  Guangzhou Guangdong People's Republic of China"},{"name":"Nanfang Glioma Center Nanfang Hospital Southern Medical University  Guangzhou Guangdong People's Republic of 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