{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:10Z","timestamp":1792043110818,"version":"4.4.0"},"reference-count":201,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>KRAS is one of the most frequently altered oncogenic drivers across human solid tumors and has long represented a central challenge in precision oncology. The clinical success of covalent KRAS G12C inhibitors has transformed a historically \u201cundruggable\u201d target into a tractable therapeutic class, but durable benefit remains limited by adaptive feedback, acquired resistance, co\u2010mutation context, and tumor\u2010lineage\u2010specific barriers. A major unresolved question is how to extend this success across diverse KRAS alleles and cancer types. This review summarizes the molecular epidemiology and therapeutic landscape of KRAS\u2010mutant cancers, with emphasis on non\u2010small cell lung cancer, colorectal cancer, and pancreatic ductal adenocarcinoma. We compare G12C\u2010directed therapy with emerging G12D\u2010, G12V\u2010, and pan\u2010KRAS strategies and dissect resistance architectures involving EGFR feedback, RTK\/MAPK\/PI3K pathway reactivation, phenotypic plasticity, stromal constraints, and immune or metabolic adaptation. We further discuss resistance\u2010informed combination therapy, targeted protein degraders, immune\u2010based approaches, antibody\u2013drug conjugates, biomarker\u2010guided sequencing, and strategies for rare KRAS variants. Particular attention is given to how allele identity, tumor lineage, and adaptive signaling jointly shape therapeutic vulnerability. By framing KRAS therapy through the \u201csame mutation, different outcomes\u201d paradigm, this review provides a context\u2010informed roadmap for extending KRAS\u2010directed precision oncology beyond G12C monotherapy.<\/jats:p>","DOI":"10.1002\/mco2.71050","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:35:53Z","timestamp":1791272153000},"source":"Crossref","is-referenced-by-count":0,"title":["KRAS Mutations in Cancers: From Undruggable Dilemma to Precision Medicine"],"prefix":"10.1002","volume":"7","author":[{"given":"Jiaying","family":"Cai","sequence":"first","affiliation":[{"name":"Clinical Medical Academy Hangzhou Medical College (HMC)  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiye","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnan","family":"Ru","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taobo","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Pharmacy Jinggangshan University  Ji'an Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihan","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Pharmacy Jinggangshan University  Ji'an Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02216-3"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16010095"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124325"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-023-01436-y"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338241264853"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084120"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020709"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S96834"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cson.2024.100069"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01375-4"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00780-4"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.21.00245"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1380584"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/29947448.2024.2427647"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01631-9"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01574-2"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-024-01055-y"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010151"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1252516"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-23-174"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12796"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2023.107942"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-023-00498-1"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199806)20:6<516::AID-BIES11>3.0.CO;2-3"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.006"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-NB2021-0362"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01839-y"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144098"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-22-639"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-07884-8"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1125547"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917239"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112541"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02524"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107966"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00221-0"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2022.101591"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204619"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00046"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00866-9"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2105281"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.04.015"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107886"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0158"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyab080"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303810"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c02272"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00434"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2024.08.005"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-69943-7"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(25)00258-9"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52324-3"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-24-02026"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02717-6"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212419"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(25)00267-5"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02696-8"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00764-8"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03688-6"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-24-0466"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-3691"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-23-0870"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319492121"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(26)00142-6"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2025.11.018"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00680"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0368"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00483"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00741"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01170"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1884-x"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-25-3725"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade3816"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.01.012"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2023.05.002"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-0383"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308795"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105074"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c00961"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.07.006"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2505783"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2504059"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2605555"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.05.016"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-25-3189"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02382-w"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.10.483"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02007-7"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07379-z"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2026.01.001"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01450-2"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2025.01.006"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00698-z"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00411"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2019-0340"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cancerbio-061521-082114"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2509012122"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2026.03.012"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119662"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.18751"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804385"},{"key":"e_1_2_13_103_1","first-page":"88","article-title":"KRAS p.G12C Mutated\u2010Targeted Treatments in Metastatic Colorectal Cancer: a Systematic Review and Meta\u2010Analysis","volume":"39","author":"Vlachou M. S.","year":"2026","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512030"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46020088"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61030408"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ads0239"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-15-0203"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1331"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020412"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1412435"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02676-9"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-026-08900-0"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.06.001"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-026-04538-9"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2600752"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16629"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-026-01579-8"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.026"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055793"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01088"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i15.4263"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.2592"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14012"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908353116"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70217-9"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2009.07.010"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.70042"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr523"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1541"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050988"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0400"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08931-1"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34225"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1340401"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-025-03734-w"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.955313"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2203968"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1611698"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205015"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13072103"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17152453"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes15101302"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1402128"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1013902"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i43.111433"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-2098"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.07.002"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2504"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102175"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI191939"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31040150"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1462808"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1006"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0027"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1676414"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01589-z"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31090385"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03362-3"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1167"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.CRC-25-0188"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.70149"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.02.014"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02903-0"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06073-w"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4123"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0386"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.11.006"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052795"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00671-9"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44026"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.103987"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02187-y"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02203-3"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010196"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-019-00972-6"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16193337"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-022-00334-z"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.831382"},{"issue":"2023","key":"e_1_2_13_180_1","article-title":"RAS\u2010Targeted Cancer Therapy: Advances in Drugging Specific Mutations","volume":"4","author":"Liu C.","year":"2020","journal-title":"MedComm"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246233"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-026-02620-x"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-026-00854-5"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0187"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17172803"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0099"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-2310"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2026.04.009"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06123-3"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjonc-2025-000946"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.109345"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0006"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-25-1346"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-25-1788"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1369136"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2026.103991"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-025-01662-4"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00733"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-24-01544"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2112431"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00465-6"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.CRC-26-0070"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.71050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:53:35Z","timestamp":1792040015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.71050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":201,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mco2.71050"],"URL":"https:\/\/doi.org\/10.1002\/mco2.71050","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"e71050"}}