{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:10Z","timestamp":1792043110093,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Patients with non\u2010small cell lung cancer (NSCLC) and brain metastases whose tumors lack EGFR, ALK, or ROS1 alterations have heterogeneous outcomes and limited evidence to guide treatment intensity. We assessed whether Lung\u2010molGPA could stratify prognosis and inform treatment selection in this population. This retrospective two\u2010center cohort included 811 patients with EGFR\/ALK\/ROS1\u2010wild\u2010type NSCLC treated between September 2013 and August 2022. Overall survival (OS) was evaluated using Kaplan\u2013Meier methods and center\u2010stratified multivariable Cox regression across three Lung\u2010molGPA strata and treatment modalities. Median OS was 6.9 months (95% confidence interval [CI], 6.4\u20137.4) overall and 4.81 (4.20\u20135.30), 7.65 (6.73\u20138.40), and 16.00 (13.40\u201322.90) months in the Lung\u2010molGPA 0\u20131.0, 1.5\u20132.0, and 2.5\u20133.0 groups, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Compared with the 0\u20131.0 group, adjusted mortality was lower in the 1.5\u20132.0 (hazard ratio [HR], 0.68; 95% CI, 0.58\u20130.80) and 2.5\u20133.0 groups (HR, 0.39; 95% CI, 0.30\u20130.50). Chemotherapy, immunotherapy, antiangiogenic therapy, and brain\u2010 and chest\u2010directed local therapy were independently associated with lower mortality, although their associations varied across prognostic strata and treatment contexts. Lung\u2010molGPA provides clinically meaningful prognostic separation and may help tailor treatment intensity for EGFR\/ALK\/ROS1\u2010wild\u2010type NSCLC with brain metastases.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71054","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:23:12Z","timestamp":1791782592000},"source":"Crossref","is-referenced-by-count":0,"title":["Optimizing Lung\u2010molGPA\u2010Directed Therapy for EGFR\/ALK\/ROS1\u2010Wildtype Non\u2010Small Cell Lung Cancer Brain Metastases: Survival Outcomes Analysis"],"prefix":"10.1002","volume":"7","author":[{"given":"Bin","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanli","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chongqing University Cancer Hospital  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.03.020"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.3834"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525082"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01255"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3485"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110405"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2012.04.001"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-024-04562-0"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.7144"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2536"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.01.020"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.12.013"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.3118"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.19.00357"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02671-2"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1093084"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2023.2272536"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.09.011"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.025"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02668"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.2756"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1478"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30391-X"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.02.175"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2204.0023"},{"issue":"2","key":"e_1_2_12_28_1","first-page":"77","article-title":"Updates to the 2024 CSCO Advanced Non\u2010small Cell Lung Cancer Guidelines","volume":"22","author":"Wang J.","year":"2025","journal-title":"Cancer Biology and Medicine"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.71054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:53:21Z","timestamp":1792040001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.71054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mco2.71054"],"URL":"https:\/\/doi.org\/10.1002\/mco2.71054","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"e71054"}}