{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:28Z","timestamp":1792043128923,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is an emerging antibiotic\u2010resistant and carcinogenic gastric pathogen. We developed nitrofuran derivatives with anti\u2010\n                    <jats:italic>H. pylori<\/jats:italic>\n                    activity and found the analog CLI\u201019\u2010009 (2\u2010nitro\u20106,7\u2010dihydrobenzofuran\u20104\u2010one N\u2010(cinnamoyl)hydrazone) inhibited\n                    <jats:italic>H. pylori<\/jats:italic>\n                    growth at 0.25\u00a0mg\/L. Notably, CLI\u201019\u2010009 contains a non\u2010conjugated hydrazone side chain, which may influence nitroreductive activation compared with classical nitrofurans and retain activity under acidic conditions. CLI\u201019\u2010009 exhibited an additive effect with clinical antibiotics and proton pump inhibitors, cleared\n                    <jats:italic>H. pylori<\/jats:italic>\n                    on gastric epithelial cells, reduced bacterial motility, and decreased vacuolation. CLI\u201019\u2010009 also showed low cytotoxicity (IC\n                    <jats:sub>50<\/jats:sub>\n                    &gt;64\u00a0mg\/L) and significantly improved survival of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010infected wax moth larvae compared with untreated controls (\n                    <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                    0.0002). Host\u2010cell RNA sequencing revealed that CLI\u201019\u2010009 treatment downregulated inflammatory genes (IL1B, IL18, IL23A, MAPK1, NFKB1, TNF, and IRAK1) during host\u2013pathogen interactions. Long\u2010term exposure generated CLI\u201019\u2010009\u2010resistant clones harboring a single\u2010nucleotide polymorphism in\n                    <jats:italic>rdxA<\/jats:italic>\n                    in both lineages, demonstrated using whole\u2010genome sequencing; this finding suggests alterations in nitroreductive activation. CLI\u201019\u2010009 showed in vitro synergy with rabeprazole and additive activity with amoxicillin, and these combinations reduced gastric inflammation and colonization compared with untreated mice when tested in a murine infection model (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001). These findings support further development of CLI\u201019\u2010009 as an anti\u2010\n                    <jats:italic>H. pylori<\/jats:italic>\n                    therapeutic alternative to clarithromycin\u2010based regimens.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71057","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:24:19Z","timestamp":1791782659000},"source":"Crossref","is-referenced-by-count":0,"title":["Acid\u2010Stable Nitrofuran Triple Therapy With Rabeprazole and Amoxicillin Targeting\u00a0\n                    <i>Helicobacter pylori<\/i>\n                    \u00a0Infection"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-3754","authenticated-orcid":false,"given":"Nagendran","family":"Tharmalingam","sequence":"first","affiliation":[{"name":"Department of Medicine Houston Methodist Research Institute  Houston Texas USA"},{"name":"Department of Medicine Weill Cornell Medicine  New 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St","family":"Laurent","sequence":"additional","affiliation":[{"name":"Koda Therapeutics  West Bridgewater Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Jones","sequence":"additional","affiliation":[{"name":"Koda Therapeutics  West Bridgewater Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Mylonakis","sequence":"additional","affiliation":[{"name":"Department of Medicine Houston Methodist Research Institute  Houston Texas USA"},{"name":"Department of Medicine Weill Cornell Medicine  New York New York 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