{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:34Z","timestamp":1792043134595,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300145"],"award-info":[{"award-number":["32300145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372986"],"award-info":[{"award-number":["32372986"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2308600"],"award-info":[{"award-number":["2023YFC2308600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018541","name":"Science Fund for Distinguished Young Scholars of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20250016"],"award-info":[{"award-number":["BK20250016"]}],"id":[{"id":"10.13039\/501100018541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bacterial pneumonia remains a leading cause of mortality and morbidity worldwide and is primarily managed through antibiotic therapy. However, the increasing threat of antimicrobial resistance underscores the urgent need for alternative strategies. In this study, we identify extracellular cyclophilin A (eCypA) as a key host factor that promotes the adherence of bacteria such as group A\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    (GAS) and\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>S. P<\/jats:italic>\n                    .). Using single\u2010nucleus RNA sequencing of mouse lung tissue, we demonstrate that eCypA upregulates the expression of integrin\/extracellular matrix adhesion receptors, including integrin \u03b15, fibronectin, and mucin, an effect largely mediated by enhancing the transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) signaling. Mechanistically, eCypA interacts with TGF\u2010\u03b2 receptor II, acting as a coactivator to increase its binding to TGF\u2010\u03b21 and amplify downstream signaling. Notably, administration of an anti\u2010CypA monoclonal antibody yields both prophylactic and therapeutic effects against GAS\u2010induced lung damage in mice by reducing bacterial adhesion and suppressing proinflammatory cytokine production. Collectively, these findings identify eCypA as a critical regulator of infection exploited by diverse bacteria that rely on integrin\/extracellular matrix for adherence, highlighting eCypA as a promising target for host\u2010directed therapies designed to mitigate bacterial attachment and subsequent inflammation.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71063","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:18:06Z","timestamp":1791875886000},"source":"Crossref","is-referenced-by-count":0,"title":["Blocking Extracellular Cyclophilin A\u2010Mediated Adhesion Protects Against Bacterial Infection"],"prefix":"10.1002","volume":"7","author":[{"given":"Xiaoyuan","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqiao","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Shenzhen Bay Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengtao","family":"Jiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Institute of Animal Science Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"National Institute of Pathogen Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Zhong","family":"Pei","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Shenzhen Bay Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqiu","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Institute of Infectious Diseases Shenzhen Bay Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runshan","family":"Lin","sequence":"additional","affiliation":[{"name":"Shenzhen Medical Academy of Research and Translation (SMART)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Medical Academy of Research and Translation (SMART)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beinan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhai","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Shenzhen Bay Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhai","family":"Bi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Medical School University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine at The Seventh Medical Center College of Pulmonary and Critical Care Medicine of The Eighth Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfa","family":"Zhang","sequence":"additional","affiliation":[{"name":"Public Health Clinical Center Affiliated to Shandong University Shandong Public Health Clinical Center Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Shenzhen Medical Academy of Research and Translation (SMART)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Medical School University of Chinese Academy of Sciences  Beijing China"},{"name":"Public Health Clinical Center Affiliated to Shandong University Shandong Public Health Clinical Center Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s44149-024-00146-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31550-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1678_19"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s44149-025-00210-w"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_2_11_7_1","unstructured":"World Health Organization Global Antibiotic Resistance Surveillance Report 2025: WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS)(World Health Organization 2026)."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2745"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-211323"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101854"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.05.005"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.3.325"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.48.100194.003101"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414422112"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00497.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/377435a0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.1.310-318.1996"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.405530"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.01.030"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.4.1672-1676.1999"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.11.3011-3013.1988"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.1999.00011.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.4902-4907.2002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109159"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/337476a0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310661"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.8.3511"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.9.789"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000130664.51010.28"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107535"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24425"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101044RRR"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110513"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.05.004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.09.033"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RU0317-090RR"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63715-7"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.03.008"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.517"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103293"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.10.047"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2680-2689.2005"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00618.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807087200"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506668103"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00432-X"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2534"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108791"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560010903"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00109-08"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-020-00378-y"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01952.x"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.74"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00760-8"},{"issue":"38","key":"e_1_2_11_56_1","first-page":"1071","article-title":"Bacterial Coinfections in Lung Tissue Specimens from Fatal Cases of 2009 Pandemic Influenza A (H1N1)\u2010United States","volume":"58","author":"Louie J.","year":"2009","journal-title":"MMWR Morbidity and Mortality"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.398-405.2005"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-308"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.07.016"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit317"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031063"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9345"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.861292"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56854-2"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1662-y"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.03.003"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"e_1_2_11_69_1","unstructured":"\u201cMouse Cell Atlas [database online] \u201dMouse Cell Atlas accessed September 11 2026 https:\/\/bis.zju.edu.cn\/MCA."},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22796"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.71063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.71063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:56:15Z","timestamp":1792040175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.71063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mco2.71063"],"URL":"https:\/\/doi.org\/10.1002\/mco2.71063","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"e71063"}}