{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:56Z","timestamp":1792043156306,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The clinical efficacy of currently available third\u2010 and later\u2010line treatment regimens for patients with metastatic colorectal cancer (mCRC) remains suboptimal. This study was designed to investigate fruquintinib plus TAS\u2010102 regimen in this patient population. This study was a prospective, multi\u2010center, single\u2010arm phase II trial. A total of 50 patients with mCRC who had experienced treatment failure to at least two standard therapies were enrolled. The primary endpoint was progression\u2010free survival (PFS) and secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and safety. Survival outcomes were estimated using the Kaplan\u2013Meier method. With a median follow\u2010up duration of 25.1 months, the median PFS was 6.07 months (95% CI: 4.07\u20137.87) and the median OS was 14.10 months (95% CI: 9.84\u201323.28). The ORR was 10.0% (95% CI: 3.3\u201321.8), with a DCR of 66.0% (95% CI: 51.2\u201378.8). All the patients experienced treatment\u2010related adverse events (TRAEs), with 68.0% reporting grade \u2265 3 TRAEs. No serious adverse events (AEs), deaths, or new safety concerns were reported. In conclusion, fruquintinib combined with TAS\u2010102 showed preliminary anti\u2010tumor activity with a manageable safety profile in patients with refractory mCRC, which highlights its potential as a viable later\u2010line therapeutic option.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : NCT05004831\n                  <\/jats:p>","DOI":"10.1002\/mco2.71070","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:23:05Z","timestamp":1791876185000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Fruquintinib Plus TAS\u2010102 in Patients With Previously Treated Metastatic Colorectal Cancer: Results From a Single\u2010Arm, Multi\u2010Center, Phase II Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Jianjun","family":"Peng","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Sun Yat\u2010sen University  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