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Using resting\u2010state functional MRI (rs\u2010fMRI) data from 306 patients with pathologically confirmed glioma at two hospitals, we delineated individualized intra\u2010 and peritumoral functional networks to quantify tumor\u2010related alterations. Two novel indices\u2014the ratio of intratumoral functional regions (RIFR) and ratio of peritumoral tumor\u2010related regions (RPTR)\u2014were proposed to describe network remodeling. Both indices were related to pathological, structural, functional, cognitive, language, and survival measures. Lower RIFR indicated diminished intratumoral connectivity and worse prognosis, while higher values reflected preserved network integration and longer survival. Models incorporating network features yielded areas under the receiver operating characteristic curve of 0.90 in training and 0.86\u20130.88 in external validation. Supporting analyses suggested that intratumoral functional regions are associated with distinct molecular and cellular characteristics. These findings suggest that intra\u2010 and peritumoral networks reflect biologically and functionally distinct tumor subregions and are associated with network\u2010level alterations, brain function, and patient outcome. Interpretation is limited by the hemodynamic basis of rs\u2010fMRI, incomplete data, and limited intraoperative validation. These findings identify individualized intra\u2010 and peritumoral connectivity measures as candidate markers of glioma\u2010associated network remodeling and prognosis that require prospective, multimodal validation.<\/jats:p>","DOI":"10.1002\/mco2.71083","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:30:12Z","timestamp":1792222212000},"source":"Crossref","is-referenced-by-count":0,"title":["Intratumoral and Peritumoral Functional Connectivity Reveals Network\u2010Level Signatures of Glioma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-6951","authenticated-orcid":false,"given":"Hongbo","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Neurosurgical Institute Capital Medical University  Beijing China"},{"name":"Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin China"},{"name":"The Russell. 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