{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:44:59Z","timestamp":1792259099493,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400138"],"award-info":[{"award-number":["82400138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900109"],"award-info":[{"award-number":["81900109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230734"],"award-info":[{"award-number":["BK20230734"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Severe aplastic anemia (SAA) is a T lymphocyte\u2010mediated bone marrow failure disorder. Only porcine ATG (p\u2010ATG) and rabbit ATG (r\u2010ATG) are available in mainland China, with the optimal first\u2010line regimen undetermined. This study compared their pharmacokinetics, efficacy, and safety. Ninety\u2010three SAA patients ineligible for transplantation or lacking a suitable donor (p\u2010ATG,\n                    <jats:italic>n<\/jats:italic>\n                    = 55; r\u2010ATG,\n                    <jats:italic>n<\/jats:italic>\n                    = 38) who were receiving immunosuppressive therapy were prospectively enrolled between 2020 and 2024. The primary endpoint was dynamic changes in lymphocyte subsets. Both ATGs peaked on treatment Day 5; r\u2010ATG cleared significantly faster, with comparable peak active concentrations. The p\u2010ATG group showed a stable early neutrophil increase, whereas the r\u2010ATG group had an initial decline, with comparable recovery at 1 month. The r\u2010ATG group exhibited prolonger lymphopenia, lower CD3\n                    <jats:sup>+<\/jats:sup>\n                    \/CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, reduced Treg cells, and higher CD19\n                    <jats:sup>+<\/jats:sup>\n                    B\u2010cell proportions. IL\u201010 was significantly elevated on day 2 after ATG administration. At 6 months, the CRR was 18.87% with p\u2010ATG and 18.92% with r\u2010ATG; ORR was 69.81% with p\u2010ATG and 56.76% with r\u2010ATG. Two\u2010year ORR and overall survival were similar, with no significant differences in infection or serum sickness. P\u2010ATG and r\u2010ATG have distinct pharmacokinetic and immunomodulatory but comparable efficacy and safety profiles, supporting interchangeable use in clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/mco2.71084","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:00:17Z","timestamp":1792256417000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety, Pharmacokinetics, and Efficacy Study of Porcine and Rabbit Antithymocyte Globulin in the Treatment of Patients With Severe Aplastic Anemia: A Multicenter, Prospective, Randomized, Open\u2010Label Clinical Trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Yawen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangsheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413485"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19236"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12605"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2021.12.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613878"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109965"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-693481"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207221085197"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103975"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.106542"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13398"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2018.01.001"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2025.117165"},{"issue":"7","key":"e_1_2_12_15_1","first-page":"2353","article-title":"Selective Lymphodepletion Underlies the Efficacy of Horse Anti\u2010Thymocyte Globulin\u2010Based Immunosuppressive Therapy in Aplastic Anemia","volume":"111","author":"Pool E. 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