{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:10:44Z","timestamp":1789834244937,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) presents as a condition marked by a sudden and rapid decrease in kidney function over a short timeframe, resulting from diverse causes. As a transcription factor, PR domain\u2010containing 16 (PRDM16), has recently been implicated in brown fat biogenesis and heart diseases. Our recent works indicated that PRDM16 could suppress the occurrence of renal interstitial fibrosis in diabetic kidney disorder. Nonetheless, the effect and regulatory mechanism of PRDM16 in AKI remain elusive. Our study demonstrated that PRDM16 inhibited apoptosis induced by ischemic\/reperfusion (I\/R) in BUMPT (Boston University mouse kidney proximal tubular) cells and HK\u20102(Human Kidney\u20102)\u00a0cells. Mechanistically, PRDM16 not only bound to the promoter region of S100 Calcium Binding Protein A6 (S100A6)and upregulated its expression but also interacted with its amino acids 945\u2013949, 957\u2013960, and 981\u2013984 to suppress the p38MAPK and JNK axes via inhibition of PKC\u2010\u03b7 activity and mitochondrial reactive oxygen species (ROS) production. Furthermore, cisplatin\u2010 and I\/R\u2010stimulated AKI progression were ameliorated in PRDM16 proximal\u2010tubule\u2010specific knockin mice, whereas exacerbated in PRDM16 knockout proximal\u2010tubule\u2010specific mice). Moreover, we observed that formononetin ameliorated I\/R\u2010 and cisplatin\u2010triggered AKI progression in mice. Taken together, these findings reveal a novel self\u2010protective mechanism in AKI, whereby PRDM16 regulates the S100A6\/PKC\u2010\u03b7\/ROS\/p38MAPK and JNK pathways to inhibit AKI progression.<\/jats:p>","DOI":"10.1002\/mco2.737","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T12:42:02Z","timestamp":1726922522000},"source":"Crossref","is-referenced-by-count":8,"title":["Overexpression of PRDM16 attenuates acute kidney injury progression: genetic and pharmacological approaches"],"prefix":"10.1002","volume":"5","author":[{"given":"Xiaozhou","family":"Li","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Emergency Medicine and Difficult Diseases Institute,Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Emergency Medicine and Difficult Diseases Institute,Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Emergency Medicine and Difficult Diseases Institute,Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liufeng","family":"Mao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Organ Procurement Organization The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Emergency Medicine and Difficult Diseases Institute,Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Wu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-4804","authenticated-orcid":false,"given":"Dongshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Emergency Medicine and Difficult Diseases Institute,Department of Emergency Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Department of Nephrology The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32563-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.339"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2017.09.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.120"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143598"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030262"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1613888"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.223"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44051"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00023.2022"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122161"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000166994"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90592.2008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07182"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.08.017"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.06.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.11.005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44271"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad154"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI99862"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1042-1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2009.09.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306704"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.037"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4621-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004738"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.252809.114"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155658"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5605"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3639"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001865"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-022-00576-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-300145"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12990"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805318200"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4805"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.06.005"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01859-5"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.04.016"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01273-4"},{"issue":"11","key":"e_1_2_10_45_1","first-page":"3439","article-title":"BML\u2010111 inhibits the inflammatory response and apoptosis of renal tissue in rats with hemorrhagic shock by inhibiting the MAPK pathway","volume":"22","author":"Chang SY","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4035310"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.41.339"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.021"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1192"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00257"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018888255"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.04.013"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8100430"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18304-z"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103859"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.07.012"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.5.F797"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04577-3"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T05:00:00Z","timestamp":1746594000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/mco2.737"],"URL":"https:\/\/doi.org\/10.1002\/mco2.737","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]},"article-number":"e737"}}