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We delineated individual\u2010specific parallel loops of CBTC through probabilistic tracking and voxel connectivity profiles\u2010based segmentation and calculated FC values in poststroke patients and healthy controls, comparing with conventional atlas\u2010based FC calculation. Support vector machine (SVM) analysis distinguished poststroke patients from controls. Connectome\u2010based predictive modeling (CPM) used FC values within CBTC circuits to predict upper limb motor function. Poststroke patients exhibited decreased ipsilesional connectivity within the individual\u2010specific CBTC circuits. SVM analysis achieved 82.8% accuracy, 76.6% sensitivity, and 89.1% specificity using individual\u2010specific parallel loops. Additionally, CPM featuring positive connections\/all connections significantly predicted Fugl\u2010Meyer assessment of upper extremity scores. There were no significant differences in the group comparisons of conventional atlas\u2010based FC values, and the FC values resulted in SVM accuracy of 75.0%, sensitivity of 67.2%, and specificity of 82.8%, with no significant CPM capability. Individual\u2010specific parallel loops show superior predictive power for assessing upper limb motor function in poststroke patients. Precise mapping of the disease\u2010related circuits is essential for understanding poststroke brain reorganization.<\/jats:p>","DOI":"10.1002\/mco2.764","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T01:51:44Z","timestamp":1728265904000},"source":"Crossref","is-referenced-by-count":14,"title":["Mapping individual cortico\u2013basal ganglia\u2013thalamo\u2013cortical circuits integrating structural and functional connectome: implications for upper limb motor impairment poststroke"],"prefix":"10.1002","volume":"5","author":[{"given":"Xin","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine 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