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In the present study, the potential involvement of the thalamus and subregions of the thalamus are explored in bipolar disorder (BD). In particular, functional and structural magnetic resonance imaging was performed on 73 adult patients with BD\u2010I and 78 healthy controls (HCs). Seed\u2010based thalamus and thalamic subregional functional connectivity (FC) were compared between the BD\u2010I patients and HCs. Compared to HCs, patients with BD\u2010I showed higher FC between the left thalamus and right lingual gyrus and altered FC between the dorsal thalamus and the default mode network and prefrontal regions, which may be correlated with mania symptomatology. In patients with BD\u2010I, the anterior subregions of the thalamus had higher FC than the posterior subregions. No significant difference in gray matter volume or local functional activity was found in the thalamus and thalamic subregions between BD\u2010I and HC. These findings provide evidence of disorganized thalamocortical FC in BD\u2010I, suggesting that the thalamus and its subregions may play important and specific roles in the neural circuitry of BD.<\/jats:p>","DOI":"10.1002\/mco2.771","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T05:22:08Z","timestamp":1730438528000},"source":"Crossref","is-referenced-by-count":8,"title":["Disorganized thalamic subregional functional connectivity in bipolar I disorder"],"prefix":"10.1002","volume":"5","author":[{"given":"Xipeng","family":"Long","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry the Fourth People's Hospital of 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