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An optimal tumor immunotherapy would ideally elicit robust innate and adaptive immune responses within tumor immune microenvironment (TIME). Unfortunately, immune system experiences functional decline with chronological age, a process termed \u201cimmunosenescence,\u201d which contributes to impaired immune responses against pathogens, suboptimal vaccination outcomes, and heightened vulnerability to various diseases, including cancer. In this context, we will elucidate hallmarks and molecular mechanisms underlying immunosenescence, detailing alterations in immunosenescence at molecular, cellular, organ, and disease levels. The role of immunosenescence in tumorigenesis and senescence\u2010related extracellular matrix (ECM) has also been addressed. Recognizing that immunosenescence is a dynamic process influenced by various factors, we will evaluate treatment strategies targeting hallmarks and molecular mechanisms, as well as methods for immune cell, organ restoration, and present emerging approaches in immunosenescence for tumor immunotherapy. The overarching goal of immunosenescence research is to prevent tumor development, recurrence, and metastasis, ultimately improving patient prognosis. Our review aims to reveal latest advancements and prospective directions in the field of immunosenescence research, offering a theoretical basis for development of practical anti\u2010immunosenescence and anti\u2010tumor strategies.<\/jats:p>","DOI":"10.1002\/mco2.777","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T03:20:24Z","timestamp":1730172024000},"source":"Crossref","is-referenced-by-count":23,"title":["Targeting immunosenescence for improved tumor immunotherapy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-742X","authenticated-orcid":false,"given":"Zaoqu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Interventional Institute of Zhengzhou University  Zhengzhou China"},{"name":"Interventional Treatment and Clinical Research Center of Henan Province  Zhengzhou 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