{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:21:26Z","timestamp":1769818886029,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000263","name":"Parkinson Society Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000263","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neural mechanisms underlying levodopa\u2010induced dyskinesia (<jats:styled-content style=\"fixed-case\">LID<\/jats:styled-content>) in Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) may involve histamine (H<jats:sub>2<\/jats:sub>) receptors on striatopallidal pathways. We recently demonstrated that the clinically available oral histamine H<jats:sub>2<\/jats:sub> receptor antagonist (H<jats:sub>2<\/jats:sub><jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), famotidine, can reduce <jats:sc>l<\/jats:sc>\u2010dopa\u2010induced chorea in <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010lesioned macaques. We hypothesized that famotidine may be useful in the treatment of <jats:styled-content style=\"fixed-case\">LID<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients. We performed a proof\u2010of\u2010concept, double\u2010blind, randomized, multiple cross\u2010over (4\u00d7) trial. Seven <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> subjects with bothersome dyskinesia were randomized to oral famotidine 80, 120, and 160\u00a0mg\/day and placebo. Each subject was randomized to receive each of the four treatment phases for 14\u00a0days followed by a 7\u2010day wash\u2010out period between each treatment phase. The primary outcome measure was change in the Unified Dyskinesia Rating Scale (<jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content>ys<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>; part <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) between placebo and famotidine. Secondary outcomes were <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content>ys<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> (parts I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>), Global Impression of Change, Lang\u2010Fahn Activities of Daily Living Dyskinesia Scale, Unified Parkinson's Disease Rating part <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, and adverse events (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s). Outcomes were evaluated pre\u2010 and post\u2010treatment per dose and analyzed using a mixed\u2010effects linear model. There was no significant effect of famotidine treatment on any of the primary or secondary outcome measures compared to placebo (each dose and all doses combined). There were no significant <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s. Even though the sample size of the current study is limited, famotidine seems to be safe in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LID<\/jats:styled-content>, but showed no potential as an antidyskinetic agent.<\/jats:p>","DOI":"10.1002\/mdc3.12061","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T08:34:51Z","timestamp":1403771691000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Famotidine, a Histamine H<sub>2<\/sub> Receptor Antagonist, Does Not Reduce Levodopa\u2010Induced Dyskinesia in Parkinson's Disease: A Proof\u2010of\u2010Concept Study"],"prefix":"10.1002","volume":"1","author":[{"given":"Tiago A.","family":"Mestre","sequence":"first","affiliation":[{"name":"Division of Neurology The Parkinson's Disease and Movement Disorder Center The Ottawa Hospital Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binit B.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Virginia Health Sciences Center McKim Hall Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara S.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine McMaster University, Hamilton Health Sciences Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-9117","authenticated-orcid":false,"given":"Camila","family":"de Aquino","sequence":"additional","affiliation":[{"name":"Division of Neurology Movement Disorders Center and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaal","family":"Al Dhakeel","sequence":"additional","affiliation":[{"name":"Division of Neurology Movement Disorders Center and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Walsh","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Tallaght Hospital and Trinity College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taneera","family":"Ghate","sequence":"additional","affiliation":[{"name":"Division of Neurology Movement Disorders Center and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane P.","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan H.","family":"Fox","sequence":"additional","affiliation":[{"name":"Division of Neurology Movement Disorders Center and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0105-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00010-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00223-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900098"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870020107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-004-0251-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.07.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23069"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(96)80177-9"},{"key":"e_1_2_7_11_1","volume-title":"Compendium of Pharmaceuticals and Specialties, Online Version (e\u2010CPS)","author":"Canadian Pharmacists Association"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91237-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22341"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20936"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25273"},{"key":"e_1_2_7_17_1","first-page":"497","article-title":"A clinician's guide for conducting randomized trials in individual patients","volume":"139","author":"Guyatt G","year":"1988","journal-title":"CMAJ"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(90)90003-K"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.00951.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060281"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmdc3.12061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmdc3.12061","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.12061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:42:42Z","timestamp":1760960562000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.12061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/mdc3.12061"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.12061","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,26]]},"assertion":[{"value":"2014-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}