{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:01:32Z","timestamp":1762254092349,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Epilepsia partialis continua (\n                      <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                      ) is defined as continuous myoclonic jerking of a body part of cortical origin and often resembles a movement disorder. Unfortunately, anti\u2010epileptic therapy is frequently ineffective. Currently, the effect of botulinum neurotoxin (Bo\n                      <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\n                      ) therapy in\n                      <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                      is controversial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed case histories, treatment protocols, and video documentation of 5 patients with\n                      <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                      , who received Bo\n                      <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\n                      therapy in our movement disorders unit. The Unified Myoclonus Rating Scale was used to document treatment effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all patients, Bo\n                      <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\n                      treatment significantly reduced severity and frequency of myoclonus and led to pronounced improvement of speech and arm utilization, regardless of etiology or duration of\n                      <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Bo\n                      <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\n                      represents a safe, effective treatment in\n                      <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                      , offering long\u2010term abatement of myoclonus. The substantial functional profit may hint at mechanisms beyond local impairment of neuromuscular transmission, such as modulation of maladaptive cortical plasticity, as observed in dystonia and poststroke spasticity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.12216","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T07:49:19Z","timestamp":1436946559000},"page":"402-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sustained Effect of Botulinum Neurotoxin in Myoclonus Owing to Epilepsia Partialis Continua"],"prefix":"10.1002","volume":"2","author":[{"given":"Janis Rebecca","family":"Bedarf","sequence":"first","affiliation":[{"name":"Department of Neurology University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Marek","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Bien","sequence":"additional","affiliation":[{"name":"Epilepsy Center Bethel Krankenhaus Mara Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian E.","family":"Elger","sequence":"additional","affiliation":[{"name":"Department of Epileptology University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Paus","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Bonn Bonn 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