{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:03:54Z","timestamp":1783825434250,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001262","name":"National Parkinson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001364","name":"University of Florida Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001364","name":"University of Florida Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008771","name":"Tourette Association of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      has proven to be an effective therapy for Parkinson's disease, essential tremor, and primary dystonia. Mixed results have been reported in case series for other hyperkinetic disorders, and sparse data are available regarding secondary movement disorders. We report on the clinical effects of bilateral globus pallidus internus (\n                      <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>\n                      i)\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      , a progressive mitochondrial cytopathy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single patient with myoclonus and dystonia syndrome secondary to a mitochondrial cytopathy with history of perinatal hypoxia was identified from our University of Florida\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      database. Demographics, clinical, surgical, and\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      data were documented.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6 months post\u2010\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      , we observed a 32% (361 to 527) improvement on quality of life (36\u2010item Medical Outcome Study Short\u2010Form Health Survey;\n                      <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\n                      \u201036). Objective clinical scales revealed a 33% (143 to 96) improvement in the Unified Myoclonus Rating Scale (\n                      <jats:styled-content style=\"fixed-case\">UMRS<\/jats:styled-content>\n                      ) total score. The\n                      <jats:styled-content style=\"fixed-case\">UMRS<\/jats:styled-content>\n                      action myoclonus subsection revealed a 29% (69 to 46) improvement. No significant changes were observed in the Burke\u2010Fahn\u2010Mardsen Dystonia Rating Scale (\n                      <jats:styled-content style=\"fixed-case\">BFMDRS<\/jats:styled-content>\n                      ). After 1\u2010year follow\u2010up, a worsening of 59% (527 to 215) was observed in the\n                      <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\n                      \u201036 scale, of 19% (28.5 to 35) in the\n                      <jats:styled-content style=\"fixed-case\">BFMDRS<\/jats:styled-content>\n                      , and of 23% (96 to 124) in the\n                      <jats:styled-content style=\"fixed-case\">UMRS<\/jats:styled-content>\n                      . However, the frequency and intensity of action myoclonus scores remained lower when compared to baseline scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although we observed a loss of benefit in the long term for most quality\u2010of\u2010life and clinical outcomes, the\n                      <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                      effects on action myoclonus seemed to remain stable. Longer follow\u2010up studies are necessary to confirm our short\u2010term and unblinded findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.12241","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T07:12:47Z","timestamp":1443510767000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Deep Brain Stimulation in a Case of Mitochondrial Disease"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8003-0610","authenticated-orcid":false,"given":"Daniel","family":"Martinez\u2010Ramirez","sequence":"first","affiliation":[{"name":"Department of Neurology University of Florida Center for Movement Disorders and Neurorestoration Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaz","family":"Hack","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida Center for Movement Disorders and Neurorestoration Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida Center for Movement Disorders and Neurorestoration Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hokuto","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida Center for Movement Disorders and Neurorestoration Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Giugni","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida Center for Movement Disorders and Neurorestoration Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine 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