{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T13:03:50Z","timestamp":1762261430829,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01NS050095"],"award-info":[{"award-number":["U01NS050095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001288","name":"Parkinson's Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004388","name":"Cephalon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The aim of this work was to identify early clinical predictors of important outcomes in Parkinson's disease (\n PD<\/jats:styled-content>\n ). In\n PD<\/jats:styled-content>\n , treatment\u2010resistant (e.g., dementia, falling) and other important functional outcomes (e.g., declines in quality of life [\n QOL<\/jats:styled-content>\n ] and activities of daily living [\n ADL<\/jats:styled-content>\n ]) emerge and become increasingly disabling.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed longitudinal data from 491 early, untreated\n PD<\/jats:styled-content>\n subjects who enrolled in the Pre\n CEPT<\/jats:styled-content>\n trial, had baseline\n SPECT<\/jats:styled-content>\n dopamine transporter deficit, and have continued in the Post\n CEPT<\/jats:styled-content>\n observational cohort. After Pre\n CEPT<\/jats:styled-content>\n , antiparkinsonian medications were added if needed. Baseline clinical precursors were examined as potential predictors of selected outcomes. Separate and multivariate logistic regressions, adjusted for certain baseline factors, were performed for dichotomized outcomes evaluated at the last Post\n CEPT<\/jats:styled-content>\n visit.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n On enrollment, subjects had average disease duration of 0.8\u00a0years and were followed for an average of 5.5\u00a0years. Some baseline precursors were found to be predictive: disease stage, cognitive, and\n ADL<\/jats:styled-content>\n scores for dementia; disease stage,\n ADL<\/jats:styled-content>\n , and motor and freezing scores for hallucinations; disease stage, depression,\n ADL<\/jats:styled-content>\n , and freezing and walking scores for falling; and\n ADL<\/jats:styled-content>\n , depression, and motor and walking scores and disease stage for\n QOL<\/jats:styled-content>\n decline. No baseline clinical feature predicted decline in\n ADL<\/jats:styled-content>\n . Being on levodopa was not a significant predictor of any outcome, but subjects on a dopamine agonist were significantly\n less<\/jats:italic>\n impaired with respect to falling, abnormal Mini\u2013Mental State Examination, and\n QOL<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Although there are limitations, results support the value of longitudinal follow\u2010up of clinical trial populations to identify early clinical precursors of important outcomes and thereby identify high\u2010risk patients early on.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mdc3.12273","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T08:46:59Z","timestamp":1450082819000},"page":"53-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early Clinical Predictors of Treatment\u2010Resistant and Functional Outcomes in Parkinson's Disease"],"prefix":"10.1002","volume":"3","author":[{"given":"Roger","family":"Kurlan","sequence":"first","affiliation":[{"name":"Atlantic Neuroscience Institute Summit New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Ravina","sequence":"additional","affiliation":[{"name":"Voyager Therapeutics Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Eberly","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology University of Rochester Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Tanner","sequence":"additional","affiliation":[{"name":"The Parkinson's Institute Sunnyvale California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Marek","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Marder","sequence":"additional","affiliation":[{"name":"Columbia University New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Beck","sequence":"additional","affiliation":[{"name":"Parkinson's Disease Foundation New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Elliott","sequence":"additional","affiliation":[{"name":"Parkinson's Disease Foundation New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Oakes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology University of Rochester Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Shoulson","sequence":"additional","affiliation":[{"name":"Georgetown University Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the PSG PostCEPT (LABS\u2010PD) 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