{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:47:06Z","timestamp":1775321226426,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T00:00:00Z","timestamp":1453075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/journal\/10.1002\/(ISSN)2330-1619\/homepage\/mdc312314-sup-v0001.htm\">View Supplementary Video 1<\/jats:ext-link><\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Swallowing deficits and freezing phenomena represent severe parkinsonian features. Freezing as a symptom occurring during swallowing has not been reported on yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report on 3 patients with probable <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>\u2010parkinsonism (<jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>\u2010P) who manifested freezing of swallowing (<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 3 patients experienced severe weight loss in recent months. At examination, 1 patient had freezing of gait. Video fluoroscopy showed nonfunctional trembling movements of the tongue and palate during chewing and volitional swallowing, with a 6\u2010 to 8\u2010Hz frequency that is typical for freezing episodes during walking and finger tapping. These freezing episodes were accompanied by impaired oral bolus transportation. The pharyngeal phase was not relevantly affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> represents a novel disease feature of <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>\u2010P. The feature may have fundamental, but potentially treatable, consequences for patients' health and quality of life and may be considered in patients with degenerative parkinsonism who experience severe and unexplained weight loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12314","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T08:20:49Z","timestamp":1453105249000},"page":"490-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Freezing of Swallowing"],"prefix":"10.1002","volume":"3","author":[{"given":"Walter","family":"Maetzler","sequence":"first","affiliation":[{"name":"Center of Neurology Department of Neurodegeneration and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"DZNE German Center for Neurodegenerative Diseases T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim W.","family":"Rattay","sequence":"additional","affiliation":[{"name":"Center of Neurology Department of Neurodegeneration and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"DZNE German Center for Neurodegenerative Diseases T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus A.","family":"Hobert","sequence":"additional","affiliation":[{"name":"Center of Neurology Department of Neurodegeneration and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"DZNE German Center for Neurodegenerative Diseases T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Center of Neurology Department of Neurodegeneration and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"DZNE German 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Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"DZNE German Center for Neurodegenerative Diseases T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Center of Neurology Department of Neurodegeneration and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Therapiezentrum University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[{"name":"INSERM U1171 Universit\u00e9 Lille Lille France"},{"name":"Pharmacologie M\u00e9dicale Centre Hospitalier R\u00e9gional Universitaire Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud 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