{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:09:38Z","timestamp":1792696178468,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Huntington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) is a genetic neurodegenerative condition that involves impairments in movement, cognition, and mood. Research is lacking in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> with regard to the prevalence of pain and the relationships between psychological factors and pain. The aim of this research was to investigate the prevalence of pain and identify the psychological factors associated with pain severity in people with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This data\u2010mining study used data from 1474 people who participated in the European Huntington's Disease Network (<jats:styled-content style=\"fixed-case\">EHDN<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">REGISTRY<\/jats:styled-content> study. Pain severity was measured using the Medical Outcome Study 36\u2010item short\u2010form health survey. Separate ordinal regression analyses were conducted with participant\u2010rated and interviewer\u2010rated psychological measures (the Hospital Anxiety and Depression Scale\u2013Snaith Irritability Scale and the Unified Huntington's Disease Rating Scale). The psychological factors considered were anxiety, depression, irritability, aggression, low self\u2010esteem, and apathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of pain in the total sample was 41% (stage I, 42%; stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, 44%; stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, 39%; stages <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and V, 50%). After controlling for confounding variables, pain severity was significantly associated with participant\u2010rated anxiety and depression. Interviewer\u2010rated anxiety, depression, and irritability also were significantly associated with severity of pain after controlling for confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This research confirmed that pain is indeed an issue for people with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>, particularly during the later stages of the disease. Caregivers and health professionals should consider the possibility that people with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> might be experiencing pain, particularly if they are showing signs of anxiety, depression, or irritability.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12376","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T08:25:46Z","timestamp":1465201546000},"page":"198-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Huntington's Disease: Prevalence and Psychological Indicators of Pain"],"prefix":"10.1002","volume":"4","author":[{"given":"Mandy","family":"Underwood","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology University of Leicester Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Bonas","sequence":"additional","affiliation":[{"name":"Department 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