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Recent advances in understanding the role of \u03b1\u2010synuclein suggest skin biopsies as a potential diagnostic or even a premotor marker of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PubMed database was searched for publications up to October 2015, and the current evidence on skin\u2010related issues in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> was comprehensively summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The evidence was summarized on the prevalence, etiology, and management of seborrheic dermatitis, sweating dysfunctions, bullous pemphigoid, and malignant melanoma, as well as therapy\u2010related skin disorders, especially those observed in amantadine, rotigotine, apomorphine, and levodopa\/carbidopa intestinal gel therapies and deep\u2010brain stimulation. Skin biopsies evaluating the presence of \u03b1\u2010synuclein, the density and morphology of cutaneous nerves, and skin fibroblast functions also are discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Skin disorders are a common manifestation of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. However, the exact pathophysiology and prevalence of these disorders are not well understood, and more systematic research is needed in this regard. Peripheral tissue biopsies as a diagnostic marker of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> are an exciting avenue in future <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> research, although multiple caveats and pending issues need to be solved before they can be used in routine clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12425","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T04:17:35Z","timestamp":1473308255000},"page":"21-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The Skin and Parkinson's Disease: Review of Clinical, Diagnostic, and Therapeutic Issues"],"prefix":"10.1002","volume":"4","author":[{"given":"Matej","family":"Skorvanek","sequence":"first","affiliation":[{"name":"Department of Neurology P. J. Safarik University Kosice Slovakia"},{"name":"Department of Neurology University Hospital L. 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